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Protonix

Protonix (Pantoprazole)

Pharmacological action

Reduces level basal hydrochloric acid secretions in a stomach. At a duodenum peptic ulcer, such depression of gastric secretion raises sensitivity of microorganism to antibiotics. Protonix (Pantoprazole) possesses own antimicrobic activity concerning H.pylori.

Indications

A stomach or duodenum Peptic ulcer in an exacerbation phase, syndrome Zollingera-Ellisona, Helicobacter pylori (in a combination with antibacterial therapy), a reflux-ezofagit.

Contraindications

The Expressed disturbances of function of kidneys, a hypersensibility to Protonix (Pantoprazole).

Side effect

The diarrhoeia, a headache Are possible; seldom - a nausea, pains in the top part of a stomach, a meteorism, an eruption, an itch, delicacy, giddiness; in single instances - edemas, a fervescence, initial implications of depressions, sight disturbances.

Special indicatings

Prior to the beginning of therapy it is necessary to exclude possibility of a malignant neoplasm in a stomach and an esophagus as Protonix (Pantoprazole) application reduces expression of symptoms and can delay an establishment of the correct diagnosis. The diagnosis of a reflux-esophagitis demands obligatory endoscopic acknowledgement.
At application for patients with disturbances of function of a liver it is necessary to supervise regularly activity of hepatic enzymes in a blood plasma and at its rising to cancel Protonix (Pantoprazole).
In need of Protonix (Pantoprazole) application at pregnancy it is necessary to correlate prospective advantage for mother and potential risk for a foetus. In case of need applications in a lactemia it is necessary to solve a question on the termination of thoracal feeding. In experimental researches it is established, that Protonix (Pantoprazole) is allocated with thoracal milk.
At simultaneous application Protonix (Pantoprazole) can change absorption of the preparations which absorption depends from pH gastric contents.
Because Protonix (Pantoprazole) is metabolized in a liver by fermental system of cytochrome P450, it is impossible to exclude possibility of medicinal interaction with the preparations metabolized by the same fermental system.

Way of application and dose

The Average therapeutic dose makes 40 mg/days the Maximum dose - 80 mg/days establish Duration of a course of therapy depending on indications, but it should not exceed 8 weeks.

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