Reglan
Reglan
Reglan (Metoclopramide)Medicinal forms
Tablets 10mg, tablets 5mg, a solution oral, a solution for 5mg/ml injections, a solution for injections 10mg, a syrup, a solution for injections of 0.5 %, a solution for intravenous and intramuscular introduction of 5mg/ml
PharmGroup
Antiemetics
International name
The Metoclopramidum
Structure
Active substance - Metoclopramidum.
Pharmacological action
Pharmacological action - antiemetic. Stimulates a motor performance of the top department GASTROINTESTINAL TRACT and normalises its motor function. Use Reglan for gastroesophageal reflux treatment (GERD cure). Strengthens a tonus and amplitude of gastric reductions, relaxs a sphincter of the gatekeeper and a duodenum bulb, raises a peristalsis. Is the antagonist of Dofaminum, suppresses the central and peripheric action of Apomorphinum, enlarges Prolactinum secretion, Aldosteronum level, sensitivity of tissues to Acetylcholinum. Quickly also it is well soaked up, the maximum concentration is reached through 1-2 h after reception of a single dose. It is deduced with urine through 72 h.
Indications to application
Nausea, vomiting, functional digestive disturbances, reflux-ezofagit, atony and stomach and duodenum hypotension; preparation for diagnostic researches GASTROINTESTINAL TRACT.
Contraindications
Hypersensitivity, glaucoma, pheochromocytoma, epilepsy, Parcinsone illness and other extrapyramidal disorders, pregnancy (I trimester), feeding by a breast (for the period of treatment it is necessary to stop thoracal feeding).
Side effect
Dryness in a mouth, a constipation or a diarrhoeia, drowsiness, depression, extrapyramidal disturbances (convulsive twitching of facial muscles, disturbances of movement of eyeballs), edemas, a galactorrhea, disturbance of a menstrual cycle, a hyperemia of a mucosa of a nose, dermal rashes.
Interaction
Neuroleptics enlarge (mutually) probability of development of extrapyramidal disorders. Strengthens a sedation of hypnagogues and alcohol. Slows down a digoxin absorption, accelerates - paracetamol, Tetracyclinum, Levodopum, ethanol.
Overdosage
Symptoms: a hypersomnia, a disorientation, extrapyramidal disorders. Treatment: as a rule, pass independently during 24 h after preparation cancellation; if necessary - appointment cholinolytic.
Special indicatings
It is necessary to consider possibility of depression of concentration of attention and augmentation of time of reaction during treatment (it is better to refuse driving of the car and work with potentially dangerous equipment). In treatment the alcohol
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