Flonase
Flonase (Fluticasone)Medicinal forms
Tablet 50mg, a tablet 100mg, a tablet 250mg, a tablet 500mg, an aerosol dosed out a 50mkg/dose 120dose, an aerosol dosed out a 25mkg/dose 120doses, an aerosol dosed out a 125mkg/dose 120doses, an aerosol dosed out a 250mkg/dose 60dose, an aerosol dosed out a 50mkg/dose 60dose, an aerosol dosed out a 25mkg/dose 60dose, an aerosol dosed out a 125mkg/dose 60dose, an aerosol dosed out a 250mkg/dose 120dose, an aerosol for inhalations dosed out a 125mkg/dose 60dose, an aerosol for inhalations dosed out a 250mkg/dose 60dose, an aerosol for inhalations dosed out a 50mkg/dose 120
International name the Fluticasone
StructureeActive substance - Fluticasone.
Pharmacological action
Antiinflammatory, antiallergic, antipruritic an effect has. Inhibits a proliferation of mast cells, eosinocytes, lymphocytes, macrophages and neutrophils, reduces production and etc. biologically active substances (Histaminum, eicosanoids,and cytokines). At use for inhalations a small part of a dose gathers in lungs, other part is swallowed, and in a liver the inactive metabolite is formed. The liver cosecretes with bile to 100 % of the dose which have got in GASTROINTESTINAL TRACT (it is deduced by an intestine). At intravenous application the period of semideducing no more than 3 hours.
Indications to application
An aerosol - preventive maintenance of exacerbations of a bronchial asthma, chronic obstructive illness of lungs, including a chronic bronchitis and an emphysema.; a cream and ointment - an eczema, a nodal prurigo, a psoriasis, neurodermatoses (including idle time deprive), red flat deprive, reactions of contact hypersensitivity, a generalised erythrosis, stings of insects, a red heat rash, a seborrheal dermatitis.
Contraindications
Hypersensitivity, pregnancy, feeding by a breast. Ointment and a cream: eels (pink, ordinary), a perioral dermatitis, a perianal and genital itch, primary lesions of a skin of a bacteriemic, virus and fungoid aetiology, thoracal age (till 1 year). A spray and an aerosol: children's age (till 4 years).
Side effect
Nose spray - the nasopharynx boring, unpleasant smack and a smell, punching of a nasal septum. An aerosol for inhalations - a candidiasis mucous a mouth, hoarseness of a voice, development of a paradoxical bronchospasm, a growth inhibition at children, a cataract, a glaucoma. A cream and ointment - a burning sensation and an itch in a drawing place, a hypopigmentation, a hypertrichosis, an allergic contact dermatitis; at long application - a symptomatic hypercorticoidism.
InteractionnThere are no data.
Overdosage Symptoms
Acute - a time depression of function of a cortex of adrenals; chronic - suppression of function of a cortex of adrenals.
Treatment
The symptomatic.
Special indicatingssWith care prescribe after system application of glucocorticoids, especially at disturbance of function of adrenals, an aerosol for inhalations - at a pulmonary tuberculosis. Nose spray is recommended to be applied with regular intervals; treatment by an aerosol for inhalations should not be stopped sharply. It is necessary to avoid hit of a cream or ointment in eyes, before applying of a new bandage a skin carefully process.
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