Amitriptyline
AmitriptylineStructure and the release form
Amitriptyline tablets on 0,025 g; 1 % a solution in ampoules on 2 ml (20 mg).
Indications
Endogenous depressions, it is disturbing-depression; neurotic conditions; some kinds of a constant pain of neurotic character.
Pharmacological action
Amitriptyline is one of the basic antidepressants representatives. Timoleptichesky action is combined at amitriptyline with the expressed sedation and appreciable cholinolytic activity. Inhibiting return capture of media even monoamines (including Noradrenalinum, Dofaminum, a serotonin), amitriptyline weakens or eliminates alarm, agitation and actually depressive implications. MAO does not cause inhibition. At long application of a preparation become perceptible sensitivity changes beta adrenergic receptors and rising of sensitivity and reactance adrenergic and serothoninenergetical structures to stimulating physiological mediators. The beginning of antidepressive action - in 2-3 weeks.
Pharmacokinetics
The preparation is well soaked up from GASTROINTESTINAL TRACT in blood at intake. It is metabolized in a liver. It is highly bound by fibers of blood and tissues (more than 90 %). It is deduced mainly by kidneys in the form of metabolites.
Side effects
Dryness in a mouth, expansion of pupils, accommodation disturbance; an emiction delay; drowsiness, giddiness, a tremor of arms, paresthesias; allergic reactions; disturbance of a warm rhythm.
Contraindications
A glaucoma; a prostatauxe, a bladder atony; a hypersensibility to a preparation.
Undesirable reactions at interaction with other medical products. Imipraminum see.
The information for the patient
Amitriptyline prescribe inside after meal, since 0,05-0,075 g, gradually enlarging a dose before reception of desirable antidepressive effect. It is necessary to use the nutrition rich with Riboflavinum, or inject it in an organism in addition in the form of vitamin preparations.
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