Anafranil
Anafranil (Clomipramine)Release form
Tablets. The tablets covered with a cover. A dragee. A solution for injections.
Farmacological action
Anafranil is antidepressant of the balanced action. In larger degree influences serotonin capture. The antidepressive effect comes rather quickly (on the first week of treatment). Possesses antihistamine activity and blocked adrenalin activity.
Anafranil Indications
Depressive syndrome of a various aetiology: endogenous, reactive, neurotic, organic, involutional; at a psychopathy, schizophrenia; at chronic pains and somatopathies. Dysthymic conditions within the limits of psychopathic disturbances at children and teenagers. Obsessional conditions and phobias. A cataplexy at a narcolepsy. A night incontience of urine (aged is more senior 5 years and after an exception of the organic reason of disorder).
Dosage
At depressions, phobias prescribe on 25 mg 2-3 times/days Within the first week a dose gradually enlarge to 50 mg 2-3 times/days After the expressed improvement of the patient translate on a maintenance dose - on 25 mg 2-3 times/days enter on 25-50 mg/sut; a dose raise every day on 25 mg up to 100-150 mg/days I.v. driply enter on 50-75 mg (into 250-500 ml of an isotonic solution of a glucose or Sodium chloridum sodium) during 1 h 1 time/days After 3-5 days of infusional therapy of the patient translate on preparation reception inside. At chronic pains the dose makes from 10 to 150 mg/days At elderly patients an initial daily dose - 10 mg; gradually, within 10 days, a dose raise to 30-50 mg/days For children an initial dose - 10 mg/days Within 10 days raise a dose at children at the age of 5-7 years to 20 mg/sut, 8-14 years - to 20-50 mg/sut, is more senior 14 years to 50 mg/sut and above.
Anafranil Side effect
In the treatment beginning - dryness in a mouth, a plentiful diaphoresis, a fine tremor, giddiness, accommodation and emiction disturbances, an orthostatic hypotension, block. Allergic dermal reactions. At application of high doses - conductivity disturbances, an arrhythmia, dream disturbances, confusion of consciousness, pavor intensifying. Seldom - disturbances of function of a liver, a hyperpyrexia, cramps, an agranulocytosis.
Special indicatings
Anafranil psychogogic action of a preparation is expressed to a lesser degree, than at Imipraminum, and the sedation - is more weak, than at amitriptyline. In treatment by a preparation it is necessary to avoid the alcohol use. At a poisoning with a preparation the gastric lavage is shown; at serious anticholinergic symptoms from party TSNS - 0 mg of Physostigminum or i.v.
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