Atarax
Atarax
Atarax (Hydroxyzine)Indications
- For putting off of excitability and a strain bound to a psychoneurotic condition and as an additional agent at treatment of organic diseases at which there is a hypererethism,
- As sedative and an antiemetic in a premedication and after application of general anaesthesia,
- As a symptomatic antipruritic agent.
For the short period it is expedient to enter Ataraxum intramusculary.
Intramuscular introduction of a preparation is especially useful in cases of emergency therapy of agitation and emotional disorders at mental and cardiologic patients, and also at acute and an alcoholism accompanied by symptoms of excitation at an abstinence. In the presence of indications of the patient can receive a preparation in the form of intramuscular injections, and then pass to intake, as more practical way of introduction.
There is no Atarax influence on effect of a digitalis, therefore it is possible to apply them in a combination with each other.
Doses and the way of introduction
Adults:
In the general practice: 25-100 mg a day in a separate dosage within day or for the night.
In psychiatry: 100-300 mg a day.
In anesthesiology: 100-200 mg a day. For a premedication Ataraxum usually prescribe at night before a surgical intervention instead of barbiturates. Ataraxum dose is necessary for selecting depending on reaction of the patient. For more short-term effect, as a rule apply half a preparation dose.
Contraindications
The preparation is contraindicative for patients with a hypersensibility to any of preparation components. Ataraxum also is contraindicative to patients with the acute form of porphyrias.
Injection forms of a preparation are intended only for intramuscular injections and it should not be entered intravenously or subcutaneously.
Interection with other preparations
Atarax action is necessary for considering, when the preparation is applied together with such depressants as narcotic both not narcotic anaesthetics and barbiturates. Therefore, when similar medical products are entered simultaneously with Atarax, their dosages should be reduced.
Patients are necessary for warning, that alcohol action can increase under the influence of Atarax.
As Atarax can strengthen action of Meperidinum and barbiturates, application of the last in the preoperative period should be modified on an individual basis.
Influence on ability to control the mechanisms
As ATARAXUM can influence attentiveness and ability to react patients should be warned about necessity to refrain from a driving and mechanisms.
Other Undesirable effects
Are weakly expressed and passing. There can be a drowsiness, delicacy, especially in the beginning of treatment by a preparation. If this effect does not disappear in some days from the therapy beginning, the preparation dose is necessary for reducing. Atarax can cause dryness in a mouth. A consensual motor performance, such as a tremor and cramps, seldom arise at appreciable excess of recommended therapeutic doses. Clinically significant respiratory depression at appointment of recommended doses it is noted.
Pregnancy and feeding by the breast
It has been noticed, that introduction of high doses of Atarax to rodents led to a pathological fetation. However, there are no data about similar influence of a preparation on the person. It is necessary to avoid Ataraxum application at pregnancy. Atarax metabolites have been found out in maternal milk. Therefore Ataraxum is contraindicative to feeding women.
The Prevention
Observation over patients with renal insufficiency in order to avoid possible accumulation of a preparation in an organism is recommended. Intramuscular injections of Ataraxum should be prescribed in area of large muscles. At unsuccessful introduction under a skin the preparation can cause appreciable damage of tissues.
Overdosage
The most frequent implication of an overdosage of a preparation is the raised sedation. As at treatment of an overdosage of any other preparation it is necessary to consider, that it could occur at reception of set of other medical products.
If spontaneous vomiting is absent, it is necessary for causing artificial by. The immediate gastric lavage also is recommended. The general supporting measures including the control over the vital functions of an organism and observation over the patient are shown. Hypotension development is improbable, however, it is possible to stop it intravenous injections of blood substitutes, application of Noradrenalinum.
The specific antidote does not exist.
Hemodialysis application at a poisoning with Ataraxum also is inexpedient. The hemodialysis is shown in cases of introduction of other preparations, such as barbiturates.
Practically there are no methods of definition of Ataraxum and biological liquids and tissues.
Storage conditions
Tablets and ampoules to store at temperature more low 25 C in a dry dark place. It is necessary to check a preparation period of validity. It is specified on packing.
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