Elavil
Elavil (Amitriptyline)Structure
Active substance - amitriptyline.
Pharmacological action
Antidepressive, sedative. Inhibits return capture of Noradrenalinum, a serotonin, etc. The presynaptic nervous terminations of neurones. At long application reduces functional activity beta adrenergic, normalises adrenergic transfer, restores the balance of these systems broken at depressions. Blocks M-M - and histaminic receptors. At it is disturbing-depressions reduces alarm, agitation and depressive implications. At the sudden termination of reception after long treatment withdrawal development is possible. Quickly also it is well soaked up and GASTROINTESTINAL TRACT. The maximum concentration in blood after intake is reached in 2,0-7,7 hours. Antidepressive action develops within 2-3 weeks after the treatment beginning. It is deduced by kidneys within several days.
The resons to buy Elavil
Indications to application
Depressions, a depressive syndrome, schizophrenic psychoses, it is disturbing-depression the various genesis, the admixed emotional disorders, behaviour disturbances, a psychogenic anorexia, a night uracrasia (auxiliary treatment), strong pains of neurogenic character.
Contraindications
Hypersensitivity, glaucoma, epilepsy, prostate hyperplasia, bladder atony, paralytic impassability of an intestine, myocardial infarction in the anamnesis, application of inhibitors MAO in previous 2 weeks, pregnancy, a lactemia, children's age (till 6 years).
Side effect
Dryness in a mouth, an emiction delay, a constipation, disturbance of sight, the accommodation, the strengthened diaphoresis. From cardiovascular system: a tachycardia, an orthostatic hypotension, pressure rising, conductivity disturbance. From party TSNS: drowsiness, giddiness, a tremor. Allergic reactions: a dermal eruption and others.
Interaction
MAO is incompatible with inhibitors. Barbiturates and carbamazepine reduce, and Cimetidinum raises concentration in plasma.
Overdosage
Symptoms: hallucinations, cramps, a coma, disturbance of warm conductivity, a hypothermia. Treatment: a gastric lavage, reception of suspension of the activated coal, laxatives, body temperature maintenance, monitoring of function of cardiovascular system not less than 5 days; at serious cholinolytic symptoms (a hypotension, an arrhythmia, a coma) - 0,5-2 g Physostigminum intramusculary or intravenously.
Special indicatings
It is not necessary to prescribe to the maniacal patient and patients with suicidal bents. With care apply at an ischemic heart disease, arrhythmias, a heart failure. During treatment it is necessary to avoid the alcohol use, and also to refuse the activity demanding special attention and speed of reactions.
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