Emsam
Emsam (Selegiline)Structure
Active substance - Selegiline.
Emsam Pharmacological action
It is irreversible MAO inhibits. Raises in central nurvise system concentration of Dofaminum and eliminates its deficiency in extrapyramidal system. Forms the metabolites suppressing return capture of Dofaminum in synapses. In a blood plasma is in the kind bound to fibers (94 %). At peroral reception it is metabolized basically in a liver. Metabolites are deduced with urine.
Indications to application
Illness Parkinson, symptomatic parkinsonism; complex therapy of an Alzheimer's disease and endogenous depressions.
Contraindications
Hypersensitivity, pregnancy, feeding by a breast (for the period of treatment the termination of thoracal feeding is obligatory).
Side effect
Alarm, fatigability, drowsiness or sleeplessness, depression, hallucinations, confusion of consciousness, disturbance of speech, a gait, a migraine, supraorbital pains, a diplopia, disorders of sexual function, an arrhythmia, orthostatic reactions, a hypotension, edemas, dryness in a mouth, a dyspepsia, a peptic ulcer exacerbation, rising of activity of transaminases, an exacerbation of a bronchial asthma, a dysuria, a hyperhidrosis, a photosensitization, a dermal eruption.
Emsam Overdosage
Symptoms: development of a "cheese" syndrome (MAO) in the form of hypertensive reactions and an exacerbation of an ischemic heart disease after the food intake inhibits all types, containing a tyramine (cheese, coffee, etc.), excitation is possible.
Special indicatings
With care prescribe at renal insufficiency, a pathology of cardiovascular system, a stomach and duodenum peptic ulcer, a glaucoma, diseases of a thyroid gland and adrenals. Reduces speed of reaction and attention on what it is necessary to inform drivers of vehicles and working with potentially dangerous mechanisms. It is necessary to consider a long after-action of a preparation in the relation MAO - till 5-7 days. Emsam is possible to prescribe in 5 weeks after Prozac cancellation.
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