Geodon
Geodon (Ziprasidone)Indications
- Preventive maintenance and treatment of schizophrenia and other alienations. The preparation is effective in therapy of productive and negative symptoms, and also affective disorders at schizophrenia.
Dosage regimen
Preparation accept inside during meal.
The recommended dose for adults makes 40 mg 2 times/days In the subsequent a dose select taking into account a clinical condition. If necessary the daily dose can be raised to maximum within 3 days. The maximum daily dose makes 160 mg (on 80 mg 2 times/sut).
At persons of advanced age, at smoking patients and at disturbance of function of kidneys it is not required to correction of a regimen of dosage.
At patients with the easy or moderately expressed disturbances of function of a liver it is expedient to lower a preparation dose. Application Geodon experience at patients with serious hepatic insufficiency is absent, therefore at this category of patients the preparation should be applied with care.
Side effect
The undesirable phenomena noted during clinical tests, meeting less than at 1 % of the patients accepting Geodon.
From party TSNS and peripheric nervous system: an asthenia, a headache, an extrapyramidal syndrome, a sleeplessness or drowsiness, a tremor, a sight illegibility, psychomotor excitation, an akathisia, giddiness, dystonic reactions. Extremely seldom there were cramps (less than at 1 % of the patients receiving Geodon). An index of disturbance of movements (Movement Disorder Burden Score), reflecting expression of extrapyramidal symptoms at Geodon application, much more low (p <0.05), than at application of Haloperidolum. Comparable changes were observed at application of a scale of an estimation of an akathisia (Simpson Angus and Barnes akathisia scales). Besides, at treatment by Haloperidolum there was above a frequency of an akathisia and application of anticholinergics, than at Geodon treatment. At long Geodon application, as well as other antipsychotic agents, there is a risk of development of dyskinesias and other remote extrapyramidal syndromes. At occurrence of signs of a dyskinesia it is expedient to lower a Geodon dose or to cancel it.
From the alimentary system: constipations, dryness in a mouth, a dyspepsia, the raised salivation, a nausea, vomiting.
The other: against a maintenance Geodon therapy rising of level of Prolactinum (it was in most cases normalised without the treatment termination), an arterial hypertensia was sometimes observed. It was informed on rising of mass of a body at 0.4 % of patients (on the average on 0.5 kg).
Pregnancy and lactemia
Geodon Application at pregnancy is contraindicative, unless the prospective advantage for mother exceeds potential risk for a foetus.
Women of genesial age should use adequate methods of contraception in Geodon application in connection with absence of clinical data about safety of its application at pregnancy.
In need of Geodon application in a lactemia thoracal feeding should be stopped.
Special indicatings
At Geodon application for the patients having in the anamnesis convulsive conditions, it is necessary to be careful.
Use in pediatrics
Efficiency and safety of Geodon application at patients is elderly till 18 years was not studied.
Influence on ability to driving of motor transport and to management of mechanisms
To the patients who are engaged in potentially dangerous kinds of activity, demanding special attention and speed of psychomotor reactions, it is necessary to be careful. Patients should be warned about possible occurrence of drowsiness against Geodon reception.
Overdosage
Data on an Geodon overdosage are limited.
Symptoms: in preregistration clinical tests at preparation reception inside in the maximum confirmed dose (3240 mg) at the patient sedative action of a preparation, a hypophrasia and a transient arterial hypertensia (a BP of 200/95 mm hg) was showed. Clinically significant changes of a warm rhythm or functional changes it did not become perceptible.
Treatment: at suspicion on an overdosage it is necessary to consider a possible role of accompanying therapy. The specific Geodon antidote is not present. At an acute overdosage it is necessary to provide passableness of respiratory tracts both adequate ventilation and oxygenation of lungs. The gastric lavage (after an intubation if the patient is without consciousness) and introduction of the activated coal in a combination to purgative preparations is possible. Possible cramps or dystonic reaction of muscles of a head and a neck after an overdosage can frame aspiration threat at the induced vomiting. It is necessary to begin immediately monitoring of function of cardiovascular system, including continuous registration of an electrocardiogram for the purpose of revealing of possible arrhythmias.
Conditions and periods of storage
The preparation should be stored in a place inaccessible to children at temperature not above 30 C. The Period of validity - 4 years.
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