Lexapro
Lexapro (Escitalopram)Indications to application
Depressive episodes of any severity level. Panic disorders from an agoraphobia.
Contraindications
Simultaneous reception of inhibitors MAO; pregnancy; the lactemia period (thoracal feeding); children's age till 15 years; a hypersensibility to Escitalopram and to other components of a preparation. To ask about contraindications to reception of Escitalopram preparation in a forum.
Side effect
From the alimentary system: most often - a nausea, appetite depression, a diarrhoeia, constipations; seldom - disturbances of gustatory sensations; are possible - vomiting, dryness in a mouth, change of laboratory indicators of function of a liver.
From party TSNS and peripheric nervous system: most often - a sleeplessness or drowsiness, giddiness, delicacy; are possible - visual disturbances, convulsive attacks, a tremor, impellent disturbances, hallucinations, a mania, confusion of consciousness, agitation, alarm, a depersonalisation, panic attacks, an acrimony.
From a metabolism: most often - the raised sweating, a hyperthermia; probably - a hyponatremia.
From sexual system: most often - an impotency, ejaculation disturbance.
From cardiovascular system: the orthostatic hypotension is possible.
Allergic reactions
Probably - anaphylactic reactions, a Quincke's disease.
Dermatological reactions: probably - a dermal eruption, an itch, ecchymomas, purpura.
The other: most often - sinusitises; probably - an arthralgia, an ischuria.
At sharp cancellation of a preparation after long application cancellation reactions - giddiness, headaches and a nausea are possible. Expression of the given reactions is insignificant, and duration is limited.
By-effects most often develop on 1 or 2 week of treatment and then usually become less intensive and arise less often at therapy continuation.
Application at pregnancy and feeding by a breast
Lexapro is contraindicative to application at pregnancy and in a lactemia (thoracal feeding).
Medicinal interaction
At simultaneous application Lexapro with inhibitors MAO, and also at the beginning of reception of inhibitors MAO patients, shortly before it stopped reception of Lexapro, occurrence of serious undesirable reactions is possible.
As cases of intensifying of action are registered at joint appointment of Lexaproand lithium or a tryptophan, it is recommended to show care at simultaneous appointment of these preparations.
Simultaneous appointment of Lexapro and the preparations containing Hypericum perforatum, can lead to augmentation of number of by-effects.
However, as well as in a case with other psychotropic drugs, simultaneous application of Lexapro and alcohol is not recommended. To learn about medicinal interactions with Escitalopram preparation.
Way of application and dose:
Lexapro prescribe 1 time/sut without dependence from food intake.
At depressive episodes the preparation is prescribed usually in a dose by of 10 mg/days Depending on individual reaction of the patient a dose can be enlarged to maximum - 20 mg/days
The antidepressive effect usually develops in 2-4 weeks after the treatment beginning. After disappearance of symptoms of depression at least still during 6 months it is necessary to continue therapy for fastening of the received effect.
At panic disorders from an agoraphobia within the first week of treatment the dose of 5 mg/sut with the subsequent augmentation to 10 mg/days Depending on individual reaction of the patient a dose is recommended can be enlarged to maximum - 20 mg/days
The maximum therapeutic effect is reached approximately through 3 months after the treatment beginning. Therapy lasts some months.
At patients of advanced age (is more senior 65 years) it is recommended to apply half of usually recommended dose (i.e. only 5 mg/sut) and lower maximum dose (10 mg/sut).
Overdosage:
Symptoms: giddiness, a tremor, agitation, drowsiness, a stupefaction, convulsive attacks, a tachycardia, electrocardiogram changes (change of segment ST and wave T, expansion of complex QRS, elongation of interval QT), arrhythmias, oppression of respiratory activity, vomiting, a metabolic acidosis, a hypopotassemia.
Treatment
The specific antidote does not exist. Treatment symptomatic and supporting: a gastric lavage, adequate oxygenation. Monitoring of function of cardiovascular and respiratory systems.
Special indicatings
The risk of fulfilment of suicide is inherent to depression and can remain before substantial improvement of the condition which have come spontaneously or owing to spent therapy. Careful observation over the patients who are on treatment with antidepressants, especially in the beginning of treatment because of possibility of clinical deterioration and-or occurrence of suicidal implications (thoughts and behaviour) is necessary. This precaution should be observed and at treatment of other alienations because of possibility of simultaneous disease by a depressive episode.
Simultaneous application of Lexapro and alcohol is not recommended.
Influence on ability to driving of motor transport and to management of mechanisms
In treatment it is not recommended to control the car or mechanisms.
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