Paxil
Paxil
Paxil (Paroxetine)Pharmacological action
Antidepressant, selective inhibitor of return capture of a serotonin. Possesses the structure which is distinct from structure of other known antidepressants.
Renders antidepressive action at expressed enough stimulating (activating) effect.
Antidepressive action is bound to ability of Paroxetine selectively to block return capture of a serotonin by a presynaptic membrane.
Influence on b-adrenoreceptors slightly, that defines the extremely weak expression of corresponding by-effects.
Indications to application
Endogenous, neurotic and situational depressions.
Dosage regimen
At intake the initial dose makes 10-20 mg/days If necessary, depending on indications, a dose raise to 40-60 mg/days dose Augmentation spend gradually - on 10 mg with an interval in 1 week. Frequency of reception - 1 time/days Treatment long. Efficiency of therapy is estimated in 6-8 weeks.
For the elderly and weakened patients, and also at disturbances of function of kidneys and a liver an initial dose - 10 mg/sut; the maximum dose - 40 mg/days
Side effects
From party TSNS: seldom (at application in doses more than 20 mg/sut) - drowsiness, a tremor, an asthenia, a sleeplessness.
From the alimentary system: seldom (at application in doses more than 20 mg/sut) - a nausea, dryness in a mouth; on occasion - constipations.
The other: seldom (at application in doses more than 20 mg/sut) - intensifying of a diaphoresis, ejaculation disturbance.
Contraindications
Simultaneous reception of inhibitors MAO and the period till 14 days after their cancellation, a hypersensibility to Paroxetine.
Special indicatings
Phase-out of Paroxetine should be spent, gradually reducing a dose, in order to avoid a withdrawal which is shown by giddiness, a nausea, vomiting, a sleeplessness, confusion of the consciousness, the raised diaphoresis.
An alcohol use is contraindicative.
With care to apply in 14 days after cancellation of inhibitors MAO, gradually enlarging a dose. Inhibitors MAO should not be prescribed within 2 weeks after full cancellation of Paroxetine.
At simultaneous application with the preparations inhibiting a metabolism of enzymes of a liver, Paroxetine is necessary to apply in the least recommended doses. At simultaneous application with the preparations inducing a metabolism of enzymes, it is not required changes of initial doses of Paxil.
With care to apply Paxil with lithium preparations (it is recommended to supervise concentration of lithium in a blood plasma), peroral anticoagulants.
In treatment patients are recommended to abstain from the alcohol use.
In experimental researches it is not established cancerogenic and mutagen properties of Paxil .
Influence on ability to driving of motor transport and to management of mechanisms
With care to apply at the patients which activity is bound to necessity of high concentration of attention and speed of psychomotor reactions.
Medicinal interaction
At simultaneous application of Paxil with a tryptophan probably development agitation, anxiety, disorders from the party GASTROINTESTINAL TRACT, including a diarrhoeia.
The metabolism and pharmacokinetic parametres of Paxil can change at simultaneous application of the preparations inducing or inhibiting an albuminous metabolism.
Paxil does not enlarge sedative action and the drowsiness bound to reception of Haloperidolum or an oxazepam.
Clinical data about interaction of inhibitors of return capture of a serotonin with lithium preparations are limited.
At simultaneous application of Paxil with Phenytoinum, other anticonvulsant preparations probably augmentation of number of by-effects.
At simultaneous application of Paxil and warfarin probably augmentation of a bleeding time at not changed prothrombin time.
Antacids and foodstuff do not influence absorption and pharmacokinetic parametres of Paroxetine.
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