Sinequan
Sinequan
Sinequan (Doxepin)Pharmacological action
Antidepressant. The action mechanism is bound to influence on adrenergic transfer in synapses and, in particular. The preparation renders sedative action. Does not cause somnolent effect. The optimum antidepressive effect is reached on 2-3rd week of treatment.
Indications
- Neurosises;
- Disturbances of a dream of a neurotic genesis;
- Psychoses (including maniacally-depressive);
- A premedication before the small surgical or diagnostic interventions which are not demanding in carrying out the general anaesthesia.
Dosage regimen
Establish individually.
At moderately expressed depression the initial dose makes 75 mg/days In the course of treatment a dose it is possible to change depending on a clinical situation; the range makes 75-150 mg/days
At serious depression the augmentation of a dose to 300 mg/sut in 2 receptions is possible. The maximum single dose makes 150 mg.
Preparation recommend to accept for the night.
Side effect
From a sight organ: visual acuity disturbance.
From the party GASTROINTESTINAL TRACT: dryness in a mouth, a constipation; sometimes - a nausea, vomiting, a dyspepsia, a diarrhoeia, disturbance of gustatory sensations, absence of appetite.
Contraindications
- A glaucoma;
- The tendency to an ischuria;
- Children's age till 12 years;
Pregnancy and lactemia
Application of a preparation in pregnancy is possible only in that case when the prospective advantage for mother exceeds potential risk for a foetus.
In need of appointment of a preparation in a lactemia it is necessary to solve a question on the termination of thoracal feeding.
Special indicatings
It is necessary to be careful at appointment Sinequan as the patient of advanced age and to the patients abusing alcohol.
At joint application Sinequan with inhibitors MAO serious by-effects (cases of a lethal outcome are known) are possible.
In the termination of therapy Sinequan is necessary to reduce its dose to full cancellation of a preparation gradually.
Influence on ability to driving of motor transport and to management of mechanisms
With care prescribe Sinequan to the patients who are engaged in potentially dangerous kinds of activity, demanding special attention and speed of psychomotor reactions.
Overdosage
Symptoms: drowsiness, a stupor, sight disturbances, dryness in a mouth. The ischuria, peristalsis depression GASTROINTESTINAL TRACT, a hyperthermia and-or a hypothermia, expansion of pupils are possible also.
Treatment: a gastric lavage and application of adsorbents. In serious cases the active maintenance therapy is necessary.
Medicinal interaction
Simultaneous of Sinequan application with the preparations metabolized with participation of cytochrome P450 IID6 (including other antidepressants, carbamazepine) can lead to rising of concentration Sinequan in plasma.
At joint application with Cimetidinum probably rising of concentration Sinequan in plasma and intensifying of its core, and also a side effect.
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