Diflucan
Diflucan
Diflucan (Fluconazole)Pharmacological action
It is active concerning Candida spp., Microsporum spp., Cryptococcus neoformans, Trichophyton spp.
Pharmacokinetics
Diflucanit is well soaked up after intake. Simultaneous food intake does not influence an absorption. Bioavailability makes 90 %. Diflucanit is widely distributed in tissues and organism organs. Its concentration in thoracal milk, an articulate liquid, a saliva, a sputum, a vaginal secret and a peritoneal liquid are similar to that in a blood plasma. Concentration in a spinal liquid makes 50-90 % from level in a blood plasma, irrespective of presence of an inflammation of cerebral covers. In a cornual layer, a false skin. The semideducing period makes 30. It is deduced by kidneys; 80 % from the entered dose - in not changed kind.
Indications
Cryptococcosis (including a cryptococcal meningitis), a system candidiasis, a candidiasis of mucosas, a vaginal candidiasis, preventive maintenance of fungoid infections at patients with the lowered immunity (including at patients AIDS). Skin mycoses, including mycoses of feet, bodies, inguinal area; an onychomycosis. Deep endemic mycoses, a sporotrichosis and a histoplasmosis at patients with normal immunity.
Dosage regimen
The individual. It is intended for intake and i.v. introduction. Depending on indications the daily dose makes 50-400 mg, frequency rate of application - 1 time/days At disturbance of function of kidneys Diflucan dose should be reduced.
Side effect
From the alimentary system: a nausea, an abdominal pain, a diarrhoeia, a meteorism.
From party TSNS: a headache, giddiness.
Allergic reactions: a dermal eruption, anaphylactic reactions.
Contraindications
Pregnancy, age till 1 year, a hypersensibility to Diflucan.
Pregnancy and lactemia
Diflucan it is contraindicative to application at pregnancy. In need of appointment in a lactemia it is necessary to solve a question on the termination of thoracal feeding.
Special indicatings
Therapy can be begun before reception of results of crops and other laboratory researches.
Medicinal interaction
At simultaneous application with rifampicin the shorting of the period of semideducing of Diflucan becomes perceptible.
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