Biaxin
Biaxin
Biaxin (Clarithromycin) $3.45Pharmacological action
Semisynthetic antibiotic of group of macroleads. Inhibits synthesis of fibers in a microbic cell. Basically bacteriostatic an effect has.
It is active concerning Gram-positive bacteria: Streptococcus spp., Staphylococcus spp., Listeria monocytogenes, Corynebacterium spp.; Gram-negative bacteria: Helicobacter pylori, Haemophilus influenzae, Haemophilus ducreyi, Moraxella catarrhalis, Bordetella pertussis, Neisseria gonorrhoeae, Neisseria meningitidis, Borrelia burgdorferi; anaerobic bacteria: Eubacterium spp., Peptococcus spp., Propionibacterium spp., Clostridium perfringens, Bacteroides melaninogenicus; intracellular microorganisms: Legionella pneumophila, Chlamydia trachomatis, Chlamydia pneumoniae, Ureaplasma urealyticum, Mycoplasma pneumoniae.
The preparation also is active concerning Toxoplasma gondii, Mycobacterium spp. (Except Mycobacterium tuberculosis).
Indications
Treatment of the infectious-inflammatory diseases caused by originators sensitive to a preparation, including:
- Infections of the top departments of respiratory tracts and ENTs-bodies;
- Infections of the bottom departments of respiratory tracts (an acute bronchitis, an exacerbation of a chronic bronchitis,atypical pneumonia);
- Infections of a skin and soft tissues;
- M.avium complex, M.kansasii, M.marinum, M.leprae and their preventive maintenance at patients AIDS;
- Helicobacter pylori at patients with a duodenum or stomach peptic ulcer (only as a part of the combined therapy);
- Other infectious-inflammatory diseases caused by microorganisms sensitive to a preparation.
Dosage regimen
To adults and children is more senior 12 years Biaxin prescribe in an average dose of 250 mg everyone 12 h.
At sinusitises, serious infections and at the diseases caused Haemophilus influenzae, the preparation is prescribed on 500 mg by everyone 12 h. The maximum daily dose - 2 Course of treatment - 8-14 days.
Helicobacter pylori at patients with a duodenum or stomach Biaxin peptic ulcer prescribe in a dose of 250-500 mg 2 times/24h as a part of the combined therapy. Course of treatment makes 7 days.
Tablets should not be broken. They should be swallowed entirely, washing down with a liquid small amount.
To children about 12 years a preparation are elderly prescribe in the form of suspension in doses from calculation of 15 mg/kg/sut in 2 receptions (through 12).
Course of treatment averages 7-14 days.
The single dose of a preparation should not exceed 500 mg. The maximum daily dose in pediatric practice - 1
For treatment and preventive maintenance of the widespread infection caused Mycobacterium avium complex, to adults and children is more senior 12 years prescribe a preparation in a dose of 500 mg everyone 12 h. The dose augmentation is If necessary possible. To children about 12 years are elderly prescribe a preparation in a dose from calculation of 15 mg/kg/24h, parted on 2 receptions (through 12). Treatment of the infection caused Mycobacterium avium complex, long.
The patient with disturbances of function of kidneys should be reduced a dose in 2 times or to double an interval between receptions.
Side effect
From the alimentary system: a nausea, vomiting, a diarrhoeia, an abdominal pain, a stomatitis, a glossitis; seldom - a pseudomembranous colitis (in case of serious and persistent diarrhoeia, a pseudomembranous colitis which can become perceptible in some cases, the preparation should be cancelled); on occasion - rising of activity of enzymes of a liver, a cholestatic icterus.
From party TSNS: giddiness, confusion of consciousness, feeling of pavor, a sleeplessness; dreadful dreamings, a headache.
Allergic reactions: an urticaria, anaphylactic reactions; very seldom - Stevens-Johnson's syndrome.
The other: time changes of gustatory sensations.
By-effects at the majority of patients are expressed slightly.
Contraindications
- Serious disturbances of function of a liver;
- A hepatitis (in the anamnesis);
- A porphyria;
- I trimester of pregnancy;
- A hypersensibility to Biaxin (Clarithromycin) and to other antibiotics from group of macroleads.
Pregnancy and lactemia
Application Biaxin (Clarithromycin) in I trimester of pregnancy is contraindicative.
Biaxin (Clarithromycin) Application in II and III trimesters of pregnancy is possible only when the expected advantage for mother exceeds potential risk for a foetus.
In need of application of a preparation in a lactemia it is necessary to stop thoracal feeding.
Special indicatings
At preparation appointment it is necessary to consider, that among antibiotics of group of macroleads there is a two-dimensional resistance.
Patients with disturbances of function of a liver of easy and average degree do not have necessity to reduce a preparation dose, if function of kidneys in norm. To patients with serious disturbances of function of kidneys the dose should be reduced.
Treatment by antibiotics changes normal flora of an intestine, development of the superinfection caused by refractory microorganisms therefore is possible.
The patient should be warned, that at a serious persistent diarrhoeia which can be caused a pseudomembranous colitis, he should address to the doctor.
Use in pediatrics
Now insufficiently given about efficiency and safety of application of a preparation at children about 6 months are elderly
Influence on ability to driving of motor transport and to management of mechanisms
The preparation does not render influence on rate of psychomotor reactions at a driving or work with mechanisms.
Overdosage
Symptoms: vomiting, an abdominal pain, a headache, confusion of consciousness.
Treatment: a gastric lavage, further spend symptomatic therapy.
Medicinal interaction
Biaxin (Clarithromycin) is metabolized in a liver and can inhibit activity of enzymes of system of cytochrome P450. At simultaneous Biaxin (Clarithromycin) application and other preparations metabolized with the assistance of specified enzymes, rising of concentration of these preparations in Serum and development of side-effects are possible.
Conditions and periods of storage
Tablets should be stored in the place protected from a moisture at temperature not above 25 C. The Period of validity - 3 years.
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