Cephalexin
CephalexinMedicinal forms
Powder for preparation of oral suspension 2.5g, a powder for suspension preparation 2.5g
Pharmacy group
Cephalosporins of the first generation
International name
Cefalexinum
Cephalexin Structure
Operating substance - Cefalexinum.
Cephalexin Pharmacological action
The antibacterial. Oppresses a transpeptidase - the enzyme participating in biosynthesis of a mucopeptide of a cellular wall of bacteria, renders bactericidal effect. It is steady in acidic medium. After intake on an empty stomach quickly and almost it is completely soaked up from GASTROINTESTINAL TRACT. Therapeutic concentration in blood remains 4-6 hours. By fibers of plasma it is bound about 15 %. Well gets into tissues (lungs, kidneys, the liver, heart), passes through a placenta, in a small amount is found out in thoracal milk. The period of semideducing from plasma makes from 30 minutes till 2 o'clock. It is deduced basically by kidneys in not changed kind, in a small amount - with bile. It is active concerning Gram-positive (staphilococcuses, streptococcuses, pneumococcuses, a diphtheritic rod) and to a lesser degree - Gram-negative microorganisms. It is steady against a penicillinase of staphilococcuses.
Indications to Cephalexin application
Infections (easy and moderate severity level) ENT-bodies (an otitis, quinsy, a sinusitis), the top and bottom respiratory tracts (a pharyngitis, a pneumonia, a bronchopneumonia, a pleura empyema, a lung abscess), genitourinary system (an acute and chronic pyelonephritis, a cystitis, an urethritis, a prostatitis, an epididymitis, gynecologic infections, a gonorrhea), a skin and soft tissues (a furunculosis, an abscess, a phlegmon, a pyoderma, a lymphangitis), bones and joints (an acute and chronic osteomyelitis).
Contraindications
Hypersensibility (including to another beta-lactamin - to Penicillinums, cephalosporins), the lactemia period. Application at pregnancy is possible, if the expected effect of therapy exceeds potential risk for a foetus.
Cephalexin Side effect
Nausea, vomiting, diarrhoeia, dryness in a mouth, absence of appetite, an abdominal pain, transitional rising of activity of serumal aminotransferases and an alkaline phosphatase, a pseudomembranous colitis, a cholestatic icterus, a hepatitis, headaches, giddiness, delicacy; a leukopenia, a neutropenia, a thrombocytopenia, a dysbacteriosis, a superinfection, allergic reactions: an itch, a dermal eruption, an urticaria, a Quincke's disease, an anaphylactic shock.
Interaction
Strengthens action of indirect anticoagulants. Furosemidum, Acidum etacrynicum and nephrotoxic antibiotics raise risk of a lesion of kidneys. Salicylases and indometacin slow down deducing.
Cephalexin Overdosage
Data are not present.
Special indicatings
With disturbance of function of kidneys correction of a regimen of dosage, since is required to patients. The cumulation is possible. With care apply (better to refuse) at presence in the anamnesis of allergic reactions to penicillinic antibiotics. Occurrence of false positive reaction to Saccharum in urine and positive reaction to test Cumbsa is possible. At a staphylococcal infection there is a two-dimensional resistance between cephalosporins.
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