Chloromycetin
Chloromycetin
Chloromycetin (Chloramphenicol)Pharmacy group
Antibiotic of group of Chloramfenicolum
Structure
1 tablet contains 250 mg of Chloramfenicolum
1 tablet contains 500 mg of Chloramfenicolum
1 capsule contains 250 mg of Chloramfenicolum
Chloromycetin Pharmacological action
Antibiotic of a wide spectrum of action. The mechanism of antimicrobic action is bound to disturbance of synthesis of fibers of microorganisms. It is active concerning Gram-positive (Staphylococcus spp., Streptococcus spp.) and Gram-negative coccuses (Neisseria gonorrhoeae, N.meningitidis), bacteria (Escherichia coli, Haemophilus influenza, Salmonella spp., Shigella spp., Klebsiella spp., Serratia spp., Yersinia spp., Proteus spp.), the spirochetes, some large viruses. The preparation is active concerning the strains steady against Penicillinum, streptomycin, Sulfanilamidums. Fastness of microorganisms to Chloramfenicolum develops rather slowly.
Chloromycetin Pharmacokinetics
At peroral reception about 90 % of a preparation it is absorbed from GASTROINTESTINAL TRACT. Communication with fiber of 45-50 %. The maximum concentration of a preparation in blood is defined through 2-3 h after peroral reception. The period of semideducing 3.5 h. The greatest concentration of a preparation is framed in a liver, kidneys, the least - in brain tissues. Well gets into mediums of an eye (except a lens) and contains in liquor in concentration of 30-50 % from its level in blood.
Indications to Chloromycetin application
The infectious-inflammatory diseases caused by microorganisms sensitive to a preparation: Typhoid; Paratyphoid; Dysentery; Tularemia; Whooping cough; Sapropyra; Trachoma; Pneumonia; Meningitis; Sepsis; Osteomyelitis.
Chloromycetin Dosage regimen
The preparation dose is established by the doctor individually. ChildrennAged till 3th years the preparation is prescribed in a dose of mass of a body by of 15 mg/kg; at the age from 3 till 8 years - 150-200 mg; is more senior 8 years - 200-400 mg. Frequency rate of reception 3-4 times a day. Duration of a course of 7-10 days.
Chloromycetin Side effect
Are possible: a nausea, vomiting, a diarrhoeia, disturbance of function of a liver, a thrombocytopenia, a leukopenia, an agranulocytosis, an aplastic anaemia, a dysbacteriosis. Seldom: a headache, depression, confusion of consciousness, a paralysis of eyeballs, an urticaria, a Quincke's disease.
Contraindications Diseases of organs of a hemopoiesis; Acute intermittent porphyria; The expressed disturbances of function of kidneys and a liver; Deficiency of enzyme gljukozo-6-fosfatdegidrogenazy; Dermal diseases (a psoriasis, an eczema, mycotic affections); Pregnancy; Lactemia; Hypersensibility to Chloramfenicolum. Special indicatings During Levomycetinum reception it is necessary to carry out the control of a picture of peripheric blood regularly.
Elase Chloromycetin Medicinal interaction
It is not recommended to prescribe Levomycetinum simultaneously with the medical products oppressing function of a hemopoiesis.
The release form 20 capsules on 250 mg
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