Cleocin

Cleocin

Cleocin (Clindamycin)

Pharmacological action

On chemical structure, the mechanism of action, concerning some species of microorganisms is more active (at 2-10 time).

The preparation well gets into liquids and organism tissues including in an osteal tissue. Through barriers between blood and a brain tissue passes badly, but at an inflammation of cerebral covers concentration in a spinal liquid considerably increases.

Indications to Cleocin application

Indications to application basically: infections of respiratory tracts, a skin and soft tissues, bones and joints, organs of an abdominal cavity, a hematosepsis (the form of infection of blood microorganisms), etc.

Way of application and dose

Before appointment it is desirable for patient of a preparation to define sensitivity to it of the microflora which have caused disease at the given patient. Preparation doses depend on gravity of disease, a condition of the patient and sensitivity of a contagium to a preparation.

The adult at infectious diseases of an abdominal cavity, as well as at others serious infections, a preparation usually prescribe in the form of injections in a dose 2,4-2,7 g a day, parted on 2-3-4 introductions. At easier forms of an infection the medical effect is reached at appointments of smaller doses of a preparation - 1,2-1,8/days of 3-4 introductions). With success doses to 4,8/days are applied

It is not recommended to prescribe more than 600 mg of Cleocin intramusculary single-step.

At an adnexitis (an inflammation of appendages of a uterus) and pel-vioperitonite (the inflammation of a peritoneum localised in the field of a small basin) enter intravenously driply in a dose 0,9 g everyone 8 h (at a simultaneous prescription of antibiotics, active concerning Gram-negative originators). Intravenous introduction of medicines is spent within, at least, 4 days and then within 48 hours after offensive of improvement of a condition of the patient. After achievement of clinical effect treatment can be continued peroral forms (for intake) a preparation on 450 mg each 6 hours before end 10-14-daily a therapy course.

Inside the preparation also is applied to treatment of infectious-inflammatory diseases easy and moderate severity level. The adult prescribe on 150-450 mg everyone 6 h. Duration of course of treatment is established individually, but at the infections caused by a beta hemolitic streptococcus, it should be continued not less than 10 days.

For treatment of infections of a neck of the uterus, caused Chlamidia trachomatis (chlamydias), - on 450 mg of a preparation 4 times a day within 10-14 days.

It is more preferable to children to prescribe a preparation in the form of a syrup. For syrup preparation in a vial with the flavoured granules it is necessary to add 60 ml of water. After that the vial contains 80 ml of a syrup with concentration of Cleocin of 75 mg in 5 ml.

For children 1 month a daily dose is more senior makes 8-25 mg/kg of mass of a body in 3-4 receptions. At children with mass of a body and less minimum recommended dose it is necessary to consider 10 kg on 1/2 teaspoons of a syrup (37,5 mg) 3 times a day.

Cleocin for children

To children the preparation for parenteral is more senior 1 month (passing a digestive tube) introductions prescribe in a dose of mass of a body of 20-40 mg/kg a day only in cases of acute necessity.

For preparation of solutions of a preparation as a dissolvent use water for injections, a normal saline solution, 5 % a glucose solution. The prepared solutions keep activity within days. Concentration of a preparation in a solution should not exceed 12 mg/ml, and rate of injection should not exceed 30 mg/minutes Duration of injection - 10-60 minutes For maintenance of desirable rate of entering of a preparation in an organism of a solution of 50 ml with concentration of 6 mg/ml are entered during 10 mines; 50 ml of a solution with concentration of 12 mg/ml - during 20 mines; 100 ml of a solution with concentration of 9 mg/ml within 30 minutes For introduction of a solution of 100 ml with concentration of 12 mg/ml is required 40 minutes

Preparation appointment in a dose exceeding 1,2 g is not recommended, at injection within an hour.

At bacteriemic vaginites (the inflammation of a vagina caused by bacteria) prescribe a vaginal cream. The single dose (one full applicator) is entered into a vagina before a dream. Course of treatment - 7 days.

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