Erythromycin
Erythromycin
ErythromycinIndications
A bronchitis, a pneumonia, a pneumopleuritis, a bronchoectatic disease, illness of legionaries; septic conditions; an erysipilatous inflammation; a mastitis, an osteomyelitis; abdominal infections (preparation for operations on an intestine), a peritonitis; a purulent otitis, sinusitises; a syphilis (at intolerance of antibiotics of other groups); a gonorrhea; a clamidiosis; preventive maintenance and diphtheria treatment; a bacteriemic endocarditis; an erythrasma. It is applied at purulent lesions of a skin, contaminated wounds, decubituses; a conjunctivitis, a blepharitis, a trachoma.
Pharmacological action
Erythromycin gets through a cellular membrane of bacteria and contacts 50S-subedinitsej bacteriemic ribosomes, indirectly oppressing fiber synthesis. Erythromycin is effective only concerning activly sharing microorganisms. It is active concerning Gram-positive and Gram-negative microorganisms, brucellas, originators of a trachoma, a syphilis. It is not active concerning micobacteria, viruses and mushrooms.
Pharmacokinetics
Bioavailability varies from 30 to 65 %, the best absorption is observed at preparation reception on an empty stomach. The peak of plasma concentration is reached in 16 hours. It is widely distributed in the majority of tissues and liquids, its high concentration are found out in a liver, bile and a lien, low - in a spinal liquid. The volume of distribution of 0,9 l/kg Communication with fibers of plasma makes 70-90 %. Erythromycin on 90 % is metabolized by enzymes of a liver with formation of inactive metabolites.
Side-effects
A nausea, vomiting, diarrhoeia; an icterus; a dysbacteriosis; allergic reactions.
Contraindications
Disturbance of function of a liver, a hypersensibility to a preparation.
Undesirable reactions at interaction with other medical products. Erythromycin raises concentration in a blood plasma of carbamazepine, Theophyllinum and strengthens their toxic effects. Application of erythromycin for patients, is long receiving indirect anticoagulants (warfarin), leads to the expressed elongation of a prothrombin time and augmentation of risk of development of a hemorrhage.
The information for the patient
usually prescribe inside the adult on 0,25 g each 4-6 hours. Accept a preparation 1-1,5 hours prior to meal, washing down with a full glass of water. At occurrence of a boring mucous a stomach a preparation accept after meal. Erythromycin passes through a placenta and it is found out in thoracal milk. The passed dose: accept the passed dose as soon as possible; do not accept it if before following reception does not remain to time; do not accept double doses.
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