Lincocin
Lincocin
Lincocin (Lincomycin)Pharmacological action
Lincocin is active concerning Gram-positive microorganisms; on Gram-negative bacteria and mushrooms does not operate. In therapeutic concentration renders bacteriostatic (interfering reproduction of bacteria) action. It is well soaked up. The maximum concentration in blood is reached through 2-4 h after introduction. Gets into an osteal tissue.
Indications to Lincocin application
Staphylococcal infections; septic processes (the diseases bound to presence in blood of microbes); osteomyelites (an inflammation of an osteal brain and an adjoining osteal tissue), caused by originators steady against Penicillinum.
Way of application and dose
Before appointment it is desirable for patient of a preparation to define sensitivity to it of the microflora which have caused disease at the given patient. The daily dose for adults at parenteral (passing a digestive tube) introduction makes 1,8 g, single - 0,6 At a serious current of an infection a daily dose can be enlarged till 2,4 the Preparation enter 3 times a day with intervals 8 h. To children prescribe in a daily dose of 10-20 mg/kg irrespective of age.
Intravenously of Lincocin a hydrochloride enter only driply with rate of 60-80 drops in a minute. Before introduction of 30 % of a solution of an antibiotic of 2 ml (0,6) dilute 250 ml of an isotonic solution of Sodium chloridum.
Duration of treatment - 7-14 days; at an osteomyelitis course of treatment to 3 weeks. And more.
Inside a preparation accept for 1-2 h to or through 2-3 h after meal as in the presence of nutrition in a stomach it is badly soaked up.
Single dose inside for adults 0,5 g, daily - 1,0-1,5 the Daily dose for children of 30-60 mg/kg (century 2+3 receptions with intervals 8-12).
Duration of treatment depending on the form and gravity of disease makes 7-14 days (at an osteomyelitis of 3 weeks and more).
The patient with is renal-hepatic Lincocin insufficiency a hydrochloride prescribe in a daily dose which is not exceeding 1,8 g, with an interval between introductions 12 h.
Lincocin Side effect
Often - a nausea, vomiting, pains in epigastriums (the area of a stomach which are settling down immediately under a place of a convergence of costal arches and a breast bone), a diarrhoeia (diarrhoeia), a glossitis (a tongue inflammation), a stomatitis. Seldom - a reversible leukopenia (depression of level of leucocytes in blood), a neutropenia, a thrombocytopenia (reduction of number of thrombocytes in blood); transitional (passing) rising of level of hepatic transaminases (enzymes) and bilirubin in a blood plasma. At intravenous introduction in the big doses the phlebitis (an inflammation of a wall of a vein) is possible. At fast intravenous introduction-dropping of arterial pressure, giddiness, delicacy. At long treatment by a preparation in high doses probably development of a pseudomembranous colitis (the intestinal colic characterised by attacks of abdominal pains and allocation of a considerable quantity of slime with a feces). Very seldom - allergic reactions in the form of an urticaria, an exfoliative dermatitis (an erubescence of all body with its expressed ecdysis), a Quincke's edema, an anaphylactic shock (allergic reaction of immediate type).
Contraindications
Disturbances of function of a liver and kidneys. The preparation should be prescribed with care the patient with the indicating to allergic reactions in the anamnesis (case history).
The release form
Capsules 0,25 g in packing on 6, 10 and 20 pieces; vials 0,5 g. 30 % a solution in ampoules on 1 ml (0,3 g in an ampoule), on 2 ml (0,6 g in an ampoule).
Storage conditions
B.Pri's list to a room temperature.
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