Vantin
Vantin
Vantin (Cefpodoxime Proxetil)Vantin is well absorbed at application inside an Aether of 3rd generation of cephalosporins - Cefpodoxime .
Cefpodoxime Proxetil concerns premedicines, turning in an active metabolite Cefpodoxime. After unitary and a multiple dose from 100 to 400 mg of a preparation through 1,9-3,1 h therapeutic concentration of 1-4,5 mg/l is reached. T1/2 fluctuates from 1,9 to 2,8 h. Absolute bioavailability reaches 50 % and can decrease at food intake, antacids and blockers of H2-histaminic receptors (Cimetidinum). In a blood plasma of 18-23 % of a preparation contacts fiber. The preparation is well distributed in organs and tissues. Approximately 90 % of Cefpodoxime after reception are excreted for 12 h with urine.
Cefpodoxime possesses antibacterial activity against Gram-positive and Gram-negative bacteria, high stability to action beta-laktamaz. To it following originators of a respiratory infection are high-strung: M (e) catarrhalis and H H.influenzae, producing and not producing beta-laktamazy, S.pneumoniae, sensitive and refractory to Penicillinum a piogenic streptococcus. The golden staphilococcus is less sensitive to Cefpodoxime. In comparison with other oral cephalosporins its antibacterial activity is highter. High activity against various strains H.influenzae has special difference.
Apply at a tonsillitis on 100 mg twice a day, and at sinusitises, a bronchitis, a pneumonia - on 200 mg 2 times a day. At size of a glomerular filtration from 10 to 40 ml/mines at the same doses a preparation 1 time a day, at a clearance of a creatinine less accept than 10 mg/ml - 1 time in 48 h.
Other preparations of 3rd generation - Cefpodoxime , Cefpodoximet - on the antimicrobial properties are close to Cefpodoxime .
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