Zithromax
Zithromax (Azithromycin)Pharmacological action
The action mechanism of Azithromycin is bound to suppression of synthesis of fiber of a microbic cell.
Pharmacokinetics
Distinctive features of Zithromax are its pharmacokinetic properties allowing:
Quickly to be soaked up from plasma in tissues and macroorganism cells;
To get in phagocytic cells and to be transported with them in the inflammation centre;
To frame high and stable therapeutic concentration in the infected tissues, remaining during 5-7 days after the termination of reception of a preparation;
To provide the long period of semideducing making 34-68 h.;
To render postantibiotic effect;
After intake Zithromax, it is well soaked up and it is quickly distributed in an organism. It is steady in acidic medium, it is lipophilic.
Indications
Infections of the top respiratory tracts and ENTs-organs (a bacteriemic pharyngitis / a tonsillitis, quinsy, a laryngitis, a sinusitis, an average otitis);
Infections of the bottom respiratory tracts (a bacteriemic bronchitis, an exacerbation of chronic obstructive illness, an intersticial alveolar pneumonia, an atypical pneumonia).
Infections of a skin and soft tissues: a chronic erratic erythema, an erypsipelas, secondary pyodermatoses, a scarlatina.
Infections of genitourinary system, including transferred sexual by.
Some experts advise to use this preparation as reserve for therapy of infectious diseases against AIDS.
Way of application and dose
Zithromax is applied perorally 1 hour prior to meal or in 2 hours after meal (simultaneous reception with nutrition reduces absorbability).
Contraindications
Zithromax is contraindicative to patients with serious disturbances of function of a liver and kidneys, at known hypersensitivity to Azithromycin or to other antibiotics-macroleads.
Application in pregnancy and a lactemia
In pregnancy and a lactemia prescribe only if the expected effect of therapy exceeds potential risk for a foetus and the child.
Side effect
Azithromycin- the representative of the most safe group of anti-infectives - macroleads.
Reactions from the party GASTROINTESTINAL TRACT (an inflation, a nausea, vomiting, diarrhoeia, an abdominal pain) can sometimes be observed.
Allergic reactions (an urticaria, a Quincke's edema, dermal rashes) can become perceptible.
Probably reversible moderate rising of activity of hepatic enzymes, neutropenia and an eosinophilia. The changed indicators come back to norm borders in 2-3 weeks after the treatment termination.
Special indicatings and safety measures
With care apply at the expressed disturbances of function of a liver, kidneys, warm arrhythmias (ventricular arrhythmias and elongation of interval QT are possible).
It is necessary to be careful at preparation appointment at easy forms of a neutropenia.
After cancellation of treatment of reaction of hypersensitivity at some patients can remain, that demands specific therapy under observation of the doctor.
Medicinal interaction
The antacids containing a hydroxide of aluminium or magnesium reduce peak concentration of Azithromycin. It is recommended to observe an interval not less than two hours between reception of Zithromax and an antacid.
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