Aceon
Aceon (Perindopril)Pharmacological action
Reduces a BP that is bound, mainly, to disturbance of formation of angiotensin II and elimination of its narrowing influence mainly on arterial vessels, and also stimulating action of angiotensin II on Aldosteronum secretion. At long Aceon application promotes restoration of elasticity of large arterial vessels, reduces a left ventricle hypertrophy.
At patients with chronic heart failure Aceon reduces a myocardium hypertrophy, reduces superfluous quantity of subendocardial collagen. Aceon normalises heart work, reducing a preload and an afterload. During treatment authentic improvement of clinical signs of a heart failure, tolerance augmentation to an exercise stress is observed.
At Aceon application for heart failure treatment in the recommended doses of the expressed changes of a BP after its first reception and after long application it is not observed. Long Aceon treatment does not lead to disturbance of function of kidneys and does not influence potassium level in blood. After intake of an average single dose the maximum hypotensive effect is reached through 46 h and remains during 24 h. BP stabilisation comes after 1 months therapies and remains for a long time.
Indications
- An arterial hypertensia;
- A chronic heart failure;
- Preventive maintenance of a repeated stroke at patients with cerebrovascular diseases in the anamnesis;
- Depression of risk of cardiovascular complications at patients from a stable ischemic heart disease.
Dosage regimen
At treatment of an essential arterial hypertensia the initial dose makes 4 mg of 1 times/sut in the morning. At an inefficiency of therapy within a month the dose can be raised to 8 mg of 1 times/days
Patients of advanced age treatment should begin with a dose of 2 mg/sut and further, if necessary, gradually to raise it up to the maximum dose of 8 mg/days
Treatment of patients with a chronic heart failure Aceon preparation in a combination with digoxin is recommended to be begun under careful medical observation, prescribing a preparation in an initial dose of 1 times/24h of 2 mg in the morning. In the subsequent, in 12 weeks of treatment, the dose can be raised to 4 mg of 1 times/days
Therapy should be begun at any time (from 2 weeks till several years) after the transferred stroke.
At patients from a stable ischemic heart disease therapy by Aceon preparation is necessary to begin with a dose of 1 times/sut of 4 mg within 2 weeks. Then the daily dose should be enlarged to 8 mg of 1 times/sut (depending on function of kidneys). Patients of advanced age should begin therapy with a dose of 1 times/sut of 2 mg within one week, then on 4 mg of 1 times/sut within the next week before augmentation of a dose to 8 mg of 1 times/sut (depending on function of kidneys).
The preparation should be accepted to meal. At the admission of reception of one or more doses it is necessary to accept 1 tablet. Before following food intake.
Side effect
From cardiovascular system: often - excessive depression of a BP and the symptoms bound to it; extremely seldom - an arrhythmia, a stenocardia, a myocardial infarction, a stroke.
From respiratory system: often - dry tussis, difficulty of breath; seldom - a bronchospasm; extremely seldom - a rhinorrhea.
From the alimentary system: often - a nausea, vomiting, an abdominal pain, a diarrhoeia, a constipation, taste disturbance; seldom-dryness in a mouth; extremely seldom - a cholestatic icterus, a pancreatitis.
From party TSNS and peripheric nervous system: often - a headache, an asthenia, giddiness, a ring in ears, sight disturbance, muscular cramps, paresthesias, taste disturbance; seldom - mood depression, dream disturbance; extremely seldom - confusion of consciousness.
Allergic reactions: often - a dermal eruption, an itch; seldom - an urticaria, a Quincke's disease.
The other: seldom - diaphoresis rising, disturbance of sex function.
From laboratory indicators: insignificant augmentation of concentration of a creatinine in urine and a blood plasma (reversible after preparation cancellation - it is the most probable at a stenosis of renal arteries, treatment of an arterial hypertensia by means of diuretics, presence of renal insufficiency), a time hyperpotassemia, a proteinuria (at patients with a glomerular nephropathy). Seldom - a thrombocytopenia, depression of haemoglobin, a hematocrit; extremely seldom - an agranulocytosis, a pancytopenia, rising of activity of hepatic transaminases, a hyperbilirubinemia.
Aceon Contraindications
- A Quincke's disease in the anamnesis;
- Pregnancy;
- Thoracal feeding;
Pregnancy and lactemia
The preparation is contraindicative to application at pregnancy.
In need of appointment of a preparation in a lactemia it is necessary to solve a question on the termination of thoracal feeding.
Aceon Special indicatings
With care it is necessary to prescribe a preparation at depression (reception of diuretics, a saltless diet, vomiting, a diarrhoeia, a hemodialysis), hyponatremias, cerebrovascular diseases, a stenocardia - risk of sharp depression of a BP; at a renovascular hypertensia, a bilateral stenosis of renal arteries or a stenosis of an artery of a unique functioning kidney - risk of development of a serious arterial hypotension and renal insufficiency; at chronic renal and a heart failure - risk of a hypopotassemia; at general diseases of a connecting tissue (HARD CURRENCY, a scleroderma) and therapies by immunodepressants (including after kidney transplantation) - risk of development of a neutropenia, an agranulocytosis; at a hyperpotassemia; at a stenosis of the aortal valve, a hypertrophic subaortic stenosis; at therapy by hypoglycemic preparations at patients with a diabetes - risk of development of a hypoglycaemia;
Aceon Overdosage
For today it has not been described any case of an overdosage. Possible symptoms: the expressed depression of a BP, a shock, a stupor, a bradycardia, disturbance of electrolytic balance, renal insufficiency.
Treatment of a possible overdosage - a gastric lavage, and then i.v. normal saline solution injection. Aceon is exposed to a dialysis (70 ml/mines).
Conditions and periods of storage
B.Preparat's list should be stored in a place inaccessible to children at temperature not above 30 C. The Period of validity - 2 years.
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