Atacand
Atacand (Candesartan)Pharmacological action
Antihypertensive preparation, the antagonist of receptors of the angiotensin II, selectively operating on receptors AT1.
Represents a promedicine which in an organism quickly turns to the active form as a result of hydrolysis at an absorption from GASTROINTESTINAL TRACT. Forms strong communication with receptors AT1 with the subsequent slow dissociation. Does not show properties of an agonist.
Against application of antagonists of receptors of angiotensin II there is no tussis that proves to be true clinical tests. Candesartan does not block other hormones and does not contact their receptors; does not influence a condition of the ionic channels participating in regulation of activity of cardiovascular system.
In patients with arterial hypertensia Atacand causes BP depression. In the beginning of treatment or at therapy renewal it was not observed serious cases of an arterial hypotension.
The therapeutic effect of a preparation is shown at all stages of an arterial hypertensia. Atacand provides smooth depression of a BP, duration of antihypertensive effect makes 24 h. Therapeutic Atacand efficiency does not depend on age or a floor of the patient.
Atacand strengthens a renal blood flow, supports or raises rate of a glomerular filtration, thus vascular resistance and filtration volume fall. The preparation does not cause changes of concentration of a glucose and structure of lipids of a blood plasma.
Indications
- An arterial hypertensia.
Dosage regimen
Atacand recommend to prescribe in a dose of 1 times/days of 8 mg the Maximum therapeutic effect it is reached in 4 weeks after the therapy beginning. In the absence of necessary clinical effect a dose it is possible to raise about 16 mg/days
Tablets accept 1 time/sut irrespective of food intake.
At appointment of a preparation with easy or moderate disturbances of function of kidneys or with chronic diseases of a liver easy or moderate severity level of correction of a regimen of dosage are not required to persons of advanced age, patients.
At appointment of a preparation to patients with the expressed disturbances of function of kidneys the initial dose should make 4 mg.
Clinical data about application of a preparation for patients with serious diseases of a liver (cirrhosis) are absent. In this connection such patients are recommended to begin treatment with a daily dose of 4 mg.
The preparation can be applied both in the form of monotherapy, and in a combination with other antihypertensive preparations (blockers of calcium channels).
Side effect
From party TSNS: often (more than 2 %) - a headache, giddiness.
From laboratory indicators: rising of activity of nuclear heating plant. As a whole it is not taped clinically significant changes of laboratory indicators at Atacand reception.
The other: often (more than 2 %) - a dorsodynia.
As a whole side-effects wore moderated and a temporality.
The Relationship of cause and effect between Atacand reception and the described by-effects is not established.
Contraindications
- Pregnancy;
- A lactemia (thoracal feeding);
- Children's and teenage age till 18 years;
- A hypersensibility to preparation components.
Pregnancy and lactemia
The preparation is contraindicative to application at pregnancy.
In experimental researches it is established, that Atacand application leads to disturbance of function of kidneys at a foetus on late terms of development, and also in the neonatal period. The mechanism of this action, possibly, is bound to influence of a preparation on system a renin-angiotensin-Aldosteronum.
At the person renal perfusion of a foetus which depends on a condition of system a renin-angiotensin-Aldosteronum, begins with II trimester of pregnancy. Thus, the risk for a foetus increases at preparation reception in II trimester.
It is not established, whether it is allocated Atacand with thoracal milk. In need of application of a preparation in a lactemia it is necessary to stop thoracal feeding in connection with potential possibility of development of negative side-effects at the child.
Special indicatings
At Atacand appointment patients with a renal artery stenosis (bilateral or at a stenosis of one artery) should consider, that the medical products influencing system a renin-angiotensin-Aldosteronum, can raise concentration of urea and a creatinine in blood serum. There is a possibility (not confirmed), that similar effects can be observed at application of antagonists of angiotensin II.
It is necessary to be careful in need of application of such combination.
Use in pediatrics
Clinical efficiency and safety of Atacand application at children is not established.
Overdosage
Cases of Atacand overdosage are not described till now.
Possible symptoms: an arterial hypotension.
Treatment: if necessary - symptomatic therapy at the constant control of vital signs. The patient should give horizontal position with the raised feet; if necessary - to enlarge volume of plasma by infusion of an isotonic solution, in the absence of effect - sympathomimetic agents. Atacand is not deduced at a hemodialysis.
Medicinal interaction
Clinically significant interaction of Atacand preparation with other medical products it is not revealed.
Conditions and periods of storage
The preparation should be stored at temperature more low 30 C. The Period of validity - 3 years.
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