Cardura
Cardura
Cardura (Doxazosin)Pharmacological action
The selective antagonist of a1-adrenoreceptors. Causes expansion of peripheric vessels that leads to reduction BP depression. Preparation action on heart function slightly also has transient character. Cardura (Doxazosin) reduces level of the maintenance of the general cholesterol, Hs-LpNp and triglycerides, enlarges maintenance Hs-LpVp in blood serum. Thus, the preparation promotes prevention of development of an atherosclerosis and an ischemic heart disease. Cardura (Doxazosin) neutral or normalising an effect has on the maintenance of insulin and a glucose in bloods, therefore a preparation it is possible to apply at sick of a diabetes. Inhibits aggregation of thrombocytes. At long treatment Doxazosin reduces left ventricle mass.
Cardura (Doxazosin) prevents reduction of unstriated muscles of the top department of an urethra and muscles of a prostate which surround an urethra. The relaxation of these muscles leads to simplification of an emiction, that considerably reduces the unpleasant symptoms observed at a good-quality hyperplasia of a prostate. Therapeutic action is shown within the first 2 weeks of treatment and amplifies at the subsequent therapy. Cardura (Doxazosin) action on a normal BP is insignificant.
Cardura is possible to apply at patients with renal insufficiency, chronic obstructive diseases of lungs and a gout.
At unitary Cardura reception duration of action makes 24 h. Action on a BP is most expressed during 2-6 h after preparation reception. The maximum effect is reached after several weeks of regular reception. If therapeutic action is not enough, patients can prescribe other antihypertensive agents: beta adrenoblockers, diuretics, blockers of calcium channels.
Indications
- Treatment of a soft and moderate arterial hypertensia (in the form of monotherapy or in a combination with other antihypertensive preparations);
- An expected treatment of a good-quality hyperplasia of a prostate.
Dosage regimen
Establish individually and correct depending on efficiency of treatment and-or development of by-effects.
At an arterial hypertensia the initial Cardura dose makes 1 mg/days the First dose it is necessary to accept in the evening before a dream. Depending on preparation action it is possible to enlarge by a BP, a dose gradually with intervals in 1-2 weeks to 2 mg, 4 mg, 8 mg of 1 times/days As a rule, average daily doses make from 2 mg to 8 mg. The maximum daily dose makes 16 mg.
At a good-quality hyperplasia of a prostate at patients with a normal BP the initial dose makes 1 mg/days the First dose it is necessary to accept in the evening before a dream. Depending on reaction to treatment, a dose it is possible to enlarge gradually with intervals in 1-2 weeks to 2 mg, 4 mg, 8 mg of 1 times/days the Average daily dose makes from 2 mg to 4 mg. The maximum daily dose - 8 mg.
At a good-quality hyperplasia of a prostate at patients with an arterial hypertensia a preparation prescribe in the same doses, as well as to patients only with an arterial hypertensia.
At patients with hepatic insufficiency a preparation apply in smaller doses.
The preparation can be accepted before, during time or after food intake.
If preparation reception during usual time is passed, it is necessary to accept this dose as soon as possible. If time for reception of the following dose it is necessary to accept only it approaches, not doubling a preparation dose. It is important to accept a preparation regularly. If the patient did not accept a preparation within several days the new therapeutic course should be begun with the least dose.
Side effect
From cardiovascular system: in the beginning of treatment and at augmentation of a dose of a preparation are possible predilection to syncopal conditions (especially at transition from a prone position or sitting in position standing), giddiness, a headache. These effects disappear independently but if they wear a difficult character or remain during long time a dose it is necessary to reduce or stop preparation reception; the tachycardia, a heart consciousness are on occasion possible.
Seldom - stenocardia aggravation, a myocardial infarction, a cerebrovascular stroke, disturbances of a warm rhythm.
From party TSNS and peripheric nervous system: the feeling of weariness, drowsiness, muscular delicacy are possible.
From the alimentary system: the nausea is possible; seldom - disturbances of indicators of function of a liver, a cholestasia, a hepatitis.
From coagulating system of blood: seldom - a thrombocytopenia, purpura, nasal bleedings.
Contraindications
- Impassability GASTROINTESTINAL TRACT or an esophagus;
- Narrowing GASTROINTESTINAL TRACT any degree;
- Children's age;
- A hypersensibility to Cardura (Doxazosin) and to other components of a preparation;
Pregnancy and lactemia
Cardura application at pregnancy is possible only under vital indications when the expected advantage of therapy for mother exceeds potential risk for a foetus.
In need of application of a preparation in a lactemia it is necessary to interrupt thoracal feeding, since safety Cardura at thoracal children is not established.
Special indicatings
Cardura does not render influence on concentration PSA (a specific antigen of a prostate).
At Cardura reception, especially the first dose, the orthostatic hypotension (syncope) is possible. In order to avoid such phenomena treatment it is necessary to begin with a dose of 1 mg in the evening before a dream. The dose should be enlarged gradually with intervals in 1-2 weeks. The patient should be warned about possibility of development of an orthostatic hypotension and to recommend to rise cautiously from a prone position or sitting. It especially concerns patients of advanced age and the patients receiving simultaneously other antihypertensive preparations or diuretics. With care apply in a combination with other antihypertensive agents, especially in the treatment beginning since intensifying of antihypertensive effect is possible.
Cardura is not recommended to apply at patients with an arterial hypotension. Before the beginning of therapy to patients with the symptoms caused by a good-quality hyperplasia of a prostate, it is necessary to spend urological inspection.
Use in pediatrics
Safety and efficiency of application in pediatrics is not established, therefore the preparation is not recommended to be prescribed to children.
Influence on ability to driving of motor transport and to management of mechanisms
In the beginning of Cardura treatment and at dose change probably excessive depression of a BP that can be accompanied by giddiness. Therefore in such cases it is not recommended to control the car and to be engaged in potentially dangerous kinds of activity.
Overdosage
Symptoms: an excessive arterial hypotension, giddiness, the syncope is possible.
Treatment: in most cases there is enough reduction of a dose or time discontinuing of therapy. The patient should give a dorsal decubitus with a low headboard and slightly raised feet. It is not recommended to cause vomiting. For deducing of not absorbed preparation from GASTROINTESTINAL TRACT it is necessary to spend a gastric lavage, to prescribe the activated coal, laxative. Prescribe agonists of a-adrenoreceptors (for example, Noradrenalinum). The hemodialysis is noneffective.
Medicinal interaction
At simultaneous Cardura application with other antihypertensive agents (blockers of b-adrenoreceptors, diuretics, blockers of calcium channels) intensifying of antihypertensive effect (application of such combination probably, however it is necessary to be careful, especially in the treatment beginning) becomes perceptible.
At simultaneous Cardura application with Sodium nitritums, anaesthetics, and also with ethanol probably intensifying of hypotensive effect (application of such combination is possible, however it is necessary to be careful, especially in the treatment beginning).
At simultaneous Cardura application with the preparations influencing rate of a metabolism in a liver, retardation (it is necessary to apply with care) is possible.
Conditions and periods of storage
The preparation should be stored at temperature not above 30 C. The Period of validity - 3 years.
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