Clonidine
Clonidine
ClonidinePharmacological action
Clonidine - the antihypertensive preparation influencing the central mechanisms of regulation of a BP. The expressed hypotensive action of a preparation is bound to depression, reduction of warm emission. The expressed sedative an effect has.
Clonidine Indications
- An arterial hypertonia of a various genesis;
- A hypertensive crisis.
Clonidine Dosage regimen
Preparation dose select individually depending on therapeutic effect and shipping of a preparation.
Tablets apply at treatment of exacerbations of a current of an arterial hypertonia. Tablets use of 75 mkg in the beginning of treatment by a preparation. Prescribe on 1/2 tablets. 2 times/days if necessary probably rising of a dose to 1-2 tablets. 2 times/days For therapy continuation, especially in need of application of high doses, recommend to use tablets of 300 mkg. Prescribe on 1/2-1 tablets. Application of a single dose of 300 mkg probably only in the conditions of a hospital. Course of treatment by a preparation should not exceed 3-4 weeks.
Clonidine Side effect
From cardiovascular system: in rare instances in the treatment beginning paradoxical rising of a BP, giddiness, an orthostatic collapse, a bradycardia are possible.
From nervous system, mentality: often - a sedation; sometimes - depressive mood, dream disorders; on occasion - paresthesias.
From a sight organ: sometimes - accommodation disorder.
From the party GASTROINTESTINAL TRACT: often - dryness in a mouth; sometimes - a constipation.
The other: sometimes - augmentation of mass of a body; on occasion - pains in a parotid gland; a gynecomastia, allergic reactions.
Clonidine Contraindications
- The expressed sinus bradycardia;
- AV blockade II, III degrees;
- Serious disturbances of a peripheric circulation;
- The expressed atherosclerosis of vessels of a brain;
- A hypersensibility to Clonidinum.
Clonidine Pregnancy and lactemia
Preparation application in I trimester of pregnancy is possible only under strict indications.
Clonidine Special indicatings
At the sharp termination of reception of a preparation probably development of a withdrawal: BP rising, nervousness, headaches, a tremor, a nausea.
At carrying out of therapy by Clonidine in a combination with beta adrenoblockers, in order to avoid undesirable rising of a BP in case of the therapy termination, at first it is necessary to finish gradually treatment by beta adrenoblockers, and then, also by a slow dose decline, to stop Clonidine reception.
Influence on ability to driving of motor transport and to management of mechanisms
During treatment by a preparation it is necessary to abstain from employment by potentially dangerous kinds of the activity demanding special attention and speed of psychomotor reactions.
Clonidine Overdosage
Intensifying of implications of the described side effects is possible.
Medicinal interaction
At simultaneous application of Clonidine with diuretic and antihistamine preparations its effects amplify.
At simultaneous application with beta adrenoblockers and-or warm glycosides the risk of development of a bradycardia and AV blockade raises.
Tolazolinum is the antagonist of Clonidine.
ClonidineConditions and periods of storage
The preparation should be stored at a room temperature. A period of storage - 5 years.
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