Doxazosin
Doxazosin
DoxazosinPharmacological action
Selective competitive blocker of a1-adrenoreceptors. After unitary reception of a preparation the maximum depression of a BP is observed during the period from 2 h to 6 h; the hypotensive effect remains during 24 h. At patients with an arterial hypertensia during treatment by Doxazosin preparation the BP does not differ in position standing and laying.
At preparation application there is a growth of factor lpvp / the GENERAL cholesterol, depression of a total level of triglycerides and cholesterol. The given beneficial effect on a lipide exchange, and also hypotensive effect of a preparation promote reduction of risk of development of an ischemic heart disease and a stroke. At long Doxazosin treatment regress of a hypertrophy of a left ventricle, suppression of aggregation of thrombocytes.
Doxazosin appointment to patients with a good-quality hyperplasia of a prostate leads to appreciable improvement urodinamic indicators and to reduction of symptoms of this disease. The effect at patients with a good-quality hyperplasia of a prostate is bound to selective blockade of a1-adrenoreceptors which are localised in a muscular stroma and a capsule of a prostate and in a bladder neck.
Indications
- An arterial hypertensia (as monotherapy and as a part of the combined antihypertensive therapy);
- A good-quality hyperplasia of a prostate (at deterioration or obstruction of outflow of urine) at patients with initially raised and normal BP.
Dosage regimen
At an arterial hypertensia the initial dose makes 1 mg/days the Dose it is possible to enlarge for achievement of desirable hypotensive effect about 1 mg to 2 mg/sut only in 1-2 weeks of reception of a preparation in a dose of 1 mg/days Further a dose enlarge by 2 mg with an interval of 1-2 weeks before achievement of desirable hypotensive effect. The maximum daily dose makes 16 mg. On the average the effect is reached at preparation application in a dose of 2-4 mg/days
At a good-quality hyperplasia of a prostate initial Doxazosin dose makes 1 mg of 1 times/days Depending on expressions of symptoms of a good-quality hyperplasia of a prostate can be enlarged a daily dose to 2 mg, and then to 4 mg. The maximum daily dose - 8 mg. The recommended interval between dose risings makes 1-2 weeks.
1 time/sut or recommend to accept in the morning a preparation in the evening.
Side effect
From cardiovascular system: the orthostatic hypotension, giddiness are possible; sometimes - a syncope; seldom - a tachycardia, edemas.
From party TSNS: seldom - a headache, delicacy, an asthenia; on occasion - sight misting.
From the alimentary system: seldom - a nausea; in single instances - disturbances of indicators of function of a liver.
From hemopoiesis system: in single instances - a thrombocytopenia, a leukopenia.
The other: seldom - a rhinitis, a dermal eruption, an itch; in single instances - an urine incontience, a long painful erection.
By-effects are usually moderately expressed and tend to pass independently at treatment continuation.
Contraindications
- A hypersensibility to Doxazosin.
Pregnancy and lactemia
In connection with absence of adequate and strictly controllable researches of safety of Doxazosin application at pregnancy and in a lactemia (thoracal feeding) preparation appointment probably only in the event that the potential advantage for mother exceeds possible risk for a foetus or the child.
Doxazosin Special indicatings
At Doxazosin appointment as the patient with disturbances of function of a liver or at its appointment in a combination with the preparations adversely influencing a liver, it is necessary to observe safety measures.
Gradual pressure decrease and orthostatic implications in the beginning of action of a preparation are similar to that at application of others selective blockers a1 - adrenoreceptors.
Unlike not selective alpha adrenoblockers, at long Doxazosin treatment of accustoming does not come, and the tachycardia is shown seldom.
Use in pediatrics
Data about safety and efficiency of application of a preparation at children and teenagers about 18 years are elderly is not available.
Influence on ability to driving of motor transport and to management of mechanisms
In the beginning of course of treatment it is recommended to abstain from employment by potentially dangerous kinds of activity, in particular from management of vehicles and mechanisms.
Overdosage
Symptoms: the expressed depression of a BP.
Treatment: the patient should give immediately horizontal position with the raised feet. Introduction of angiotonic preparations is if necessary shown. The hemodialysis is noneffective.
Medicinal interaction
It is noted adverse interaction at simultaneous Doxazosin application with diuretics, Furosemidum, beta adrenoblockers, blockers of calcium channels, antibiotics, peroral hypoglycemic preparations, indirect anticoagulants and uricosuric preparations.
Doxazosin does not influence linkage with fibers of plasma of digoxin, Phenytoinum, warfarin, indometacin.
Conditions and periods of storage
The preparation should be stored at a room temperature (from 15 to 25 C). The Period of validity - 4 years.
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