Mevacor
Mevacor (Lovastatin)Pharmacological action
Hypolipidemichesky preparation. Inhibits cholesterol synthesis in a liver at a stage mevalon acids.
Mevacor reduces concentration of cholesterol, triglycerides, possessing antiatherogenous action.
Indications
- Treatment of a primary hypercholesterinemia at an inefficiency of a dietetics with the limited maintenance of sated Adepses and cholesterol, and also other pharmacological methods of treatment;
Dosage regimen
To patients with the expressed hypercholesterinemia prescribe in the treatment beginning on 20 mg/sut, unitary, during a supper.
To patients with a moderate hypercholesterinemia - on 10 mg/sut, unitary, during a supper.
The maintenance dose makes 10-80 mg/sut, unitary or in stages. The maximum daily dose makes 80 mg/days
The preparation dose should be reduced, if level cholesterol/lpnp decreases to 75 mg/100 of ml (1.94 mmol/l) or level of the general cholesterol in blood will decrease to 140 mg/100 of ml (3.6 mmol/l).
It is not necessary to change a regimen of dosage more often, than each 4 weeks.
To the patients accepting immunodepressants, the preparation should be prescribed in a dose of 10 mg/days the Maximum daily dose for such patients makes 20 mg/days
To patients with serious renal insufficiency should not be prescribed Mevacor in doses more than 20 mg/days If application of higher doses is necessary for these patients, the preparation should be applied with extra care.
Side effect
From the alimentary system: a constipation (4.9 %), a diarrhoeia (5.5 %), digestion disturbances (3.9 %), an eructation (6.4 %), pains in epigastric area (5.7 %), a heartburn (1.6 %), a nausea (4.7 %); vomiting, dryness in a mouth, taste disturbances (0 %); seldom - long and substantial increase of activity of hepatic transaminases, an alkaline phosphatase, bilirubin; in single instances - an acute pancreatitis (communication between occurrence of this side effect and preparation application is not confirmed).
From osteomuscular system: muscular spastic strictures (1.1 %), muscular pains (2.4 %); pains in a thorax, pains in the bottom extremities, brachialgias, articulate pains (0 %); seldom - a myopathy, rising of activity of more often after transplantation of organs.
From party TSNS: giddiness (2 %), a headache (9.3 %), sight disturbances (1.5 %); a sleeplessness, paresthesias (0 %).
Dermal reactions: an eruption, an itch (5.2 %).
The other: a baldness (0 %).
Contraindications
- The expressed disturbances of function of a liver or proof rising of level of hepatic transaminases in blood serum;
- Pregnancy;
- A lactemia;
- Children's and teenage age till 18 years;
- A hypersensibility to a preparation.
Pregnancy and lactemia
Mevacor application is contraindicative at pregnancy.
Women of genital age can apply Mevacor only against application of reliable methods of contraception.
If during Mevacor treatment there is a pregnancy, the preparation should be cancelled, and the woman should be informed on potential danger to a foetus.
There are no the data, concerning Mevacor allocation and its metabolites with thoracal milk, therefore it is not necessary to apply a preparation in a lactemia.
Special indicatings
Before Mevacor appointment is necessary to carry out the actions referred on change of a way of life of the patient: diet observance, motor performance rising, depression of mass of a body.
It is recommended to interrupt periodically Mevacor treatment at such conditions as serious infections, an arterial hypotension, extensive surgical interventions, traumas, serious metabolic, endocrine or electrolytic disturbances, and also uncontrollable cramps.
The preparation should be applied with care to the patients abusing alcohol or having in the anamnesis of disturbance of function of a liver.
Mevacor can raise activity of hepatic transaminases in blood serum (to value in 3 times exceeding admissible level at adult patients), that becomes perceptible through 3-12 months after the treatment beginning. Value are normalised gradually after preparation cancellation. Therefore before the treatment beginning, and also after 6-12-months the period of therapy or at augmentation of a dose of a preparation, it is necessary to define level of hepatic transaminases in blood serum. If activity of hepatic transaminases is enlarged more than in 3 times in comparison with the top border of norm, Mevacor therapy should be cancelled.
Mevacor can sometimes cause a myopathy shown by muscular pains.
It is necessary to warn the patient about necessity to inform the doctor about all by-effects, such as muscular pains, the general delicacy, and especially if these symptoms are accompanied by a fervescence and bad state of health.
Mevacor is less effective at patients with a homozygous family hypercholesterinemia (there are no LPNP-RECEPTORS). These patients have a high probability of rising of level of hepatic transaminases in blood serum.
Use in pediatrics
Safety and efficiency of application of a preparation at children are not established.
Influence on ability to driving of motor transport and to management of mechanisms
In connection with possible occurrence of giddiness, headaches against Mevacor application is necessary to refrain from performance of the work demanding speed of psychomotor reactions and special attention.
It is necessary to observe extra care in the beginning of course of treatment by a preparation.
Overdosage
Symptoms: intensifying of implications of the described side effects is possible. At Mevacor reception in a dose 5-6 g at patients it did not become perceptible specific side effects, their general condition did not change.
Treatment: the specific antidote is not present. It is necessary to spend an expected treatment.
Medicinal interaction
Simultaneous Mevacor application with immunodepressants, nicotinic acid, erythromycin, cyclosporine, other antimicotic preparations of this group, with inhibitors of HIV-proteases raises risk of development of a myopathy.
Conditions and periods of storage
To store in the place protected from light at temperature to 25 C. The Period of validity 2 years.
Buy Mevacor online
Here you can order Mevacor online. Cheap generic Mevacor, just click the link below.
Drug Search
Certificates
We accept
Mastercard and other