Albendazole
AlbendazolePharmacological action
The basic mechanism of action is bound to inhibiting effect on polymerisation beta-tubulina which conducts to a destruction of cytoplasmatic microcanaliculuses of cells of an intestinal tract of helminths; changes a current of biochemical processes (suppresses glucose recycling), blocks movement of secretory granules and other organellas in muscular cells of roundworms, causing their destruction. It is most active concerning larval forms - Echinococcus granulosus and Taenia solium; nematodes - Strongyloides stercolatis.
Indications
- Nematodoses (an ascariasis, an enterobiosis, a necatoriasis);
- The admixed helminthic invasions;
- caused by larval form Taenia solium;
- An echinococcosis of a liver, lungs, a peritoneum, caused by larval form Echinococcus granulosus;
- A lambliasis;
Dosage regimen
The average therapeutic dose at treatment of nematodoses for adults and children is more senior 2 years makes 400 mg unitary.
At an echinococcosis to patients with mass of a body 60 kg and more a preparation prescribe on 400 mg 2 times/sut, with mass of a body less than 60 kg a dose establish of 15 mg/kg/sut parted on 2 receptions from calculation. The maximum daily dose - 800 mg. At an echinococcosis - 3 cycles for 28 days with a 14-day interval between cycles.
At a lambliasis to children the preparation is prescribed from calculation of 1 times/sut by of 10-15 mg/kg within 5-7 days.
To adults and children than 60 kg a preparation are more senior 14 years with mass of a body more apply in a single dose of 400 mg; with mass of a body less than 60 kg - 200 mg, to children are more younger 14 years a dose establish from calculation of 10 mg/kg. Frequency rate of reception 2 times/sut, duration of therapy of 7-14 days.
Preparation accept during food intake. It is recommended to spend simultaneous treatment of all members of a family.
Side effect
From the alimentary system: disturbance of function of a liver with change of functional hepatic tests (weak or moderate rising of activity of transaminases), pains in the field of a stomach, a nausea, vomiting.
From hemopoiesis system: a leukopenia, a granulocytopenia, an agranulocytosis, a thrombocytopenia, a pancytopenia.
From party TSNS: a headache, giddiness, meningeal symptoms.
Dermatological reactions: a reversible alopecia, a dermal eruption, an itch.
The other: rise in temperature, BP rising, acute renal insufficiency, allergic reactions.
Contraindications
- A retina lesion;
- Pregnancy;
With care apply at hemopoiesis disturbance, disturbances of function of a liver (to and during treatment it is necessary to supervise regularly liver function).
Pregnancy and lactemia
The preparation is contraindicative to application at pregnancy. In need of appointment of a preparation in a lactemia it is necessary to solve a question on the termination of thoracal feeding.
Before preparation appointment it is necessary to be convinced of absence of pregnancy at women of genital age. In therapy it is necessary to use reliable methods of contraception.
Special indicatings
The control of laboratory indicators
Against preparation application recommend to supervise cellular structure of blood.
At leukopenia occurrence stop therapy.
Overdosage
Treatment: a gastric lavage, the activated coal. If necessary spend symptomatic therapy.
Conditions and periods of storage
B.Preparat's list should be stored in dry, protected from light, a place inaccessible to children, at temperature more low 25 C. The Period of validity - 3 years.
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