Imuran
Imuran (Azathioprine)Pharmacological action
Immunodepressive agent. Influences synthesis RNA and DNA, brakes expansion of the immunocompetent cells, the immune answer dependent on T-cages.
Indications
Preventive maintenance of reaction of a graft rejection (as a part of the combined therapy). The Pseudorheumatism of a serious current, a chronic hepatitis, a system lupus erythematosus, a dermatomyositis, a nodous periarteritis, the idiopathic Werlhof's disease, the got hemolitic anaemia, a gangrenous pyoderma.
Dosage
Establish individually taking into account the nosological form and gravity of a current of disease, a dosage of simultaneously prescribed preparations, hematological shipping. For preventive maintenance of reaction of a graft rejection prescribe in a shock dose of 5 mgkgsut in 2-3 receptions within 1-2 months; then pass to a maintenance dose from 1 to 4 mgkgsut within several years. In other cases the daily dose makes 1-2 mgkg. Treatment long.
Side effect
A leukopenia, a thrombocytopenia, an anaemia), development of secondary infections, a macrocytosis, a nausea, vomiting, an anorexia, a dermal eruption, arthralgias, a medicinal fever, a cholestatic hepatitis. At recipients of grafts the pancreatitis, erozivno-ulcer lesions and bleedings from GASTROINTESTINAL TRACT, a necrosis and intestine punching are noted. There are individual reports on development of acute renal insufficiency, a hemolitic anaemia, acute pulmonary diseases, meningeal reactions.
Contraindications
Pregnancy, hypersensibility to Azathioprinum and-or Mercaptopurinum.
Special indicatings
Within the first 8 weeks of treatment the weekly control of a picture of peripheric blood, in the subsequent - 1-2 times a month is shown. To patients with disturbance of function of kidneys and-or a liver, and also at simultaneous reception of Allopyrinolum it is necessary to prescribe lower doses of Azathioprinum.
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