Levitra Professional
Pharmacological actionThe medicine intensifies natural reaction of the organism on sexual simulation.
Patients with insignificant erectile dysfunction can feel the effect of erection within 10 minutes from a dose of 10mg. Patients with severe dysfunction can feel the similar effect in 25 min.
Pharmacological action: about 8-12h
The medication is characterized by a high rate of absorption.
Patients with kidney or hepatic failure observed no changes of pharmacokinetic indexes.
Contraindication
The medication should not be used by people with acute hepatic failure, severe kidney diseases, people after apoplectic or heart attack. Not recommended for under 16-year-olds.
Dosage regimen
Intake, irrespective of food acceptance. The recommended starting dose is 10 mg 25-60 min before the sexual contact. The maximum recommended intake is once per day. For proper effect, sufficient sexual stimulation is required.
Depending on the effective action and personal acceptability, the dose could be increased to 20 mg or lowered to 5 mg per day. The maximum daily dose is 20 mg.
Patients with imperceptible hepatic failure do not need any changes of dosage regimen. The starting dose for patients with moderately severe kidney failure is 5 mg per day. Depending on the effective action and treatment acceptability, the dose can be increased to 10 mg and later to 20 mg.
Patients with imperceptible and moderately severe kidney failure dot not need any changes of dosage regimen.
Side effect
10% of cases: headache, flushing or stuffy nose.
Interaction of Levitra (vardenafil) with other medications
Simultaneous usage with alpha-adrenoblocker can cause blood depression, that's why vardenafil should be taken not earlier than in 6 h after alpha-adrenoblocker intake.
There was observed no significant pharmacokinetic reaction from vardenafil treatment with glibenclamid, nifedipine, warfarin and digoxin. Simultaneous usage with warfarin caused no changes of prothrombin time and clotting factors.
Simultaneous usage with acetylsalicylic acid, antacids, ACE inhibitors, beta-blockers, diuretics, hypoglycemic medications (sulfonylurea and metformin), ranitidine, caused no changes of vardenafil pharmacokinetics.
Monotherapy with vardenafil does not arrest thrombocyte aggregation, caused by different thrombocyte agonists. Vardenafil usage of higher concentration than therapeutic causes insignificant dose-dependent action of increased antiaggregant effect of natrium nitroprusside, producing NO.
Overdosage
Symptoms: backache without any signs of toxic action to muscular or nervous system. Treatment: nosotropic. Can not be cleared via haemodialysis.
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