Well-known, that the cells allocated from a connecting tissue forming bones, are the unique cells, capable to form a skeleton. However recent researches have shown, that the specialised blood cells having the general parentage with leucocytes, allocated of an osteal brain, are capable to form bones in the sites kept away from the basic skeleton.
The given work published on-line in August, 2009 in magazine Stem Cells, - first signs as proof of that circulating blood cells can be involved in abnormal formation of bones.

Opening of that circulating blood cells can generate a bone out of a normal skeleton, has been made at studying of rare genetic disease - ossifying fibrodysplasia progressing. At this disease there is a formation of a secondary skeleton as a result of transformation of a normal muscular tissue in a bone. This process is caused by a mutation of the gene coding a receptor to BMP (bone morphogenetic proteins-fibers of a morphgenesis of an osteal tissue, are members of family of transforming factors of the growth participating in development almost of all organs and tissues and, first of all, in a bookmark of a dorsoventral axis).

"Identification of circulating cells with bones-forming in potential at people has great value at fibrodysplasia, as well as at more general disturbances of formation of bones out of a skeleton at such disease, as an end-stage of illness of the aortal valve, accompanied by damage head and a spinal cord, and at hip and patella replacement. This aberrant growth type of bones also occurs owing to serious traumas. Its research can help to understand to us how bones after the termination of growth of a skeleton are formed, and results can throw light on the diseases of bones shown in insufficient or their incomplete formation", - the doctor of medicine Robert Dzh speaks. Robert J. Pignolo, the senior lecturer of School of medicine University of Pennsylvania (the University of Pennsylvania School of Medicine) and the director of Clinic for an osteoporosis and bound to it diseases of bones in Ralston-Penn (Ralston-Penn Clinic for Osteoporosis and Related Bone Disorders).

Researchers have analysed samples of blood from the patients sick fibrodysplasia, and healthy people (control group), having isolated the cells forming a bone at hypodermic transplantation by an animal. The isolated cells were characterized on the superficial and other markers which have confirmed that is cells of a medullar parentage. At research of biopsies of an abnormal bone from patients with fibrodysplasia it was revealed, that it contains the medullar cells migrating in places of primary damage of a tissue.

"This research serves as an explanation of how forming bones of a cell could find damage and inflammation sites where subsequently there was outskeletal an ossification, - the doctor of medicine S.Kaplan speaks, - doctor Pignolo and researchers from its laboratory have proved, that these circulating cells possess affinity to the damaged tissue".