Aspirin
Aspirin
AspirinPharmacological action
The preparation renders febrifugal, antiinflammatory action, and also reduces aggregation of thrombocytes. The basic mechanism of action of Acidum acetylsalicylicum is the inactivation of enzyme of cyclooxygenase therefore synthesis of Prostaglandinums is broken. Owing to reduction of production of Prostaglandinums pyrogenic influence of Prostaglandinums on the thermoregulation centres decreases. Sensitising influence of Prostaglandinums on sensitive nerve terminations (that leads to dropping of their sensitivity to pain mediators) besides, decreases.
At the same time, it is necessary to consider, that Acidum acetylsalicylicum quenches also cyclooxygenase of endothelial cells in. However cyclooxygenase of endothelial cells is less sensitive to action of Acidum acetylsalicylicum and, unlike enzyme of thrombocytes, is quenched reversible.
Aspirin Indications
- Cupping of an acute attack of a migraine;
- A pain syndrome of weak and average intensity various (including inflammatory) a genesis;
- A fever at infectious-inflammatory diseases;
- Rheumatic diseases;
- Preventive maintenance of clottages and embolisms;
- Preventive maintenance and treatment of transitional ischemic disturbances of a cerebral circulation;
- Preventive maintenance of a myocardial infarction at patients with an astable stenocardia;
- Secondary preventive maintenance of a myocardial infarction.
Aspirin Dosing regimen
Preparation prescribe inside.
At a pain syndrome (including an inflammatory genesis), feverish states, rheumatic diseases the single dose for adults compounds 0 g, daily - to 3 g; for children the single dose - 250-750 mg, daily - is more senior 0 5 years
If necessary it is possible to accept a single dose 3 times/sut with an interval 4-8 h.
For cupping of an attack of a migraine the single dose compounds 1 g, a daily dose - 3
For preventive maintenance and treatment of disturbances of a cerebral circulation the preparation is prescribed in a dose by of 125-300 mg/days
At an astable stenocardia and for secondary preventive maintenance of a myocardial infarction the average daily dose of Acidum acetylsalicylicum compounds 300-325 mg. The preparation daily dose is recommended to be divided into 3 receptions.
At patients with concomitant disturbances of function of a liver or nephroses it is necessary to reduce a dose or to enlarge an interval between receptions.
Tablets can be solved in water before reception or to swallow entirely, washing down with water or other fluid (to 1/2 glasses).
Aspirin Side effect
From the party GASTROINTESTINAL TRACT: the nausea, an anorexia, pains in epigastric range are possible; on occasion (especially at frequent and long application of a preparation) - erozivno-ulcer lesions GASTROINTESTINAL TRACT, the latent hemorrhage from GASTROINTESTINAL TRACT, signs of a gastrointestinal bleeding.
From hemopoiesis system: very seldom - a thrombocytopenia, an anaemia (owing to concealed hemorrhages from GASTROINTESTINAL TRACT).
Allergic responses: seldom (especially at patients with a bronchial asthma) - a dermal eruption, a bronchospasm.
Contraindications
- A stomach and duodenum peptic ulcer in an exacerbation phase;
- The raised predilection to hemorrhages;
- Diseases of nephroses;
- Simultaneous treatment by anticoagulants, Heparinum (except for therapy by low doses of Heparinum at the frequent and careful control over coagulability);
- Deficiency gljukozo-6-fosfatdegidrogenazy;
- A bronchial asthma;
- Chronic or relapsing dyspeptic symptoms, and also a stomach ulcer and a duodenum in the anamnesis;
- Disturbances of function of nephroses and-or a liver;
- Pregnancy;
- Hypersensitivity to Acidum acetylsalicylicum and other Salicylases, to other allergenic materials.
Aspirin Pregnancy and lactemia
The preparation is contraindicative to application in pregnancy. It is necessary to consider, that reception of Salicylases in I trimester of pregnancy bind in many epidemiological researches to the raised risk of development of teratisms (the wolf mouth, heart diseases). However at use of average therapeutic doses this risk, apparently, is insignificant, as the research spent approximately on 3200 mothers exhibited pairs and the child, has not taped communication with the raised percent of teratisms. At mother and the child the raised predilection to bleedings was observed. At reception of a preparation Aspirin mother shortly before sorts at newborns (especially not full-term) intracranial bleedings are possible.
In a lactemia at reception of a preparation Aspirin in average doses of discontinuing of thoracal feeding, as a rule, is not required. At regular reception of high doses of a preparation it is necessary to solve a question on the termination of thoracal feeding.
The special indicatings
To children and teenagers with the diseases accompanied by a hyperthermia, Aspirin is desirable for prescribing only at an inefficiency of other preparations. If at appointment of a preparation Aspirin takes place longly incessant vomiting.
At patients with allergic diseases, including a bronchial asthma, an allergic and hay rhinitis, an urticaria, a dermal itch, an edema of a mucosa and nose polyps, and also in a combination to persistent infections of respiratory tracts, at patients with hypersensitivity to analgetics and antirheumatic preparations of any phylum probably development of attacks of a bronchial asthma.
In preparation application it is necessary to abstain from the alcohol use.
Aspirin Overdosage
Symptoms: at an easy intoxication the nausea, vomiting, pains in epigastriums, and also (especially at children and elderly patients) a sonitus, giddiness, headaches, sight and audition depression are possible. At an appreciable overdosage there is an incoherent thinking, confusion of consciousness, drowsiness, a collapse, a tremor, a dyspnea, a dyspnea, dehydration, a hyperthermia, a coma, alkali reaction of urine, a metabolic acidosis, a respiratory (gas) alkalosis, carbohydrate metabolism disturbances.
Lethal dose of Acidum acetylsalicylicum for adults - more than 10 h, for children - more than 3
Treatment: depending on a state of acid-base equilibrium and electrolytic balance spend injection of solutions of Natrii hydrocarbonas, sodium of Citras or Sodium lactatum sodium.
Medicinal interaction
At joint application of Aspirin and anticoagulants the risk of development of a bleeding raises.
Against treatment by Aspirin Methotrexatum side effect is aggravated.
Appointment of antiacid agents against treatment by Aspirin (especially in doses more than 3 g for adults and more than 1.5 g for children) can invoke depression of high steady level of Salicylas in blood.
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