Azulfidine
Azulfidine
Azulfidine (Sulfasalazine)Pharmacological action
Preparation for treatment of illness the Crone. Azulfidine selectively collects in a connecting tissue of an intestine with liberation of 5-aminosalicylic acid possessing antiinflammatory activity, and Sulfapyridinum, having antimicrobic an effect in the relation streptococcuses, an intestinal rod.
Azulfidine Indications
- A nonspecific ulcerative colitis (treatment of exacerbations and a maintenance therapy in a remission phase);
- Illness the Crone (lungs forms in an exacerbation phase);
- A pseudorheumatism;
- a pseudorheumatism.
Azulfidine Dosage regimen
At illnesses the Crone in the first day of treatment prescribe the adult on 500 mg 4 times/24h; in 2nd day - on 1 g 4 times/24h; in 3rd and next days - on 1 g 4 times/days After acute clinical symptoms of disease prescribe a preparation in a maintenance dose on 500 mg 3-4 times/24h within several months.
To children at the age of 5-7 years prescribe on 250-500 mg of 3-6 times/24h, to children is more senior 7 years - on 500 mg of 3-6 times/days
At a pseudorheumatism the adult within the first week a preparation prescribe on 500 mg of 1 times/24h; within 2 weeks - on 500 mg 2 times/24h; within 3 weeks - on 500 mg 3 times/24h etc. the Therapeutic daily dose to Azulfidine can make from 1.5 till 3 Course of treatment - 6 months and more.
To children 6 years the preparation aged is more senior prescribe in a dose of mass of the body/24h of 30-50 mg/kg, parted on 2-4 receptions; for children is more senior 16 years - the maximum daily dose makes 2
The preparation should be accepted after meal.
Azulfidine Side effect
From party TSNS and peripheric nervous system: a headache, giddiness, a sonitus, cramps, disturbances of a dream, hallucination, a peripheric neuropathy.
From the alimentary system: a nausea, vomiting, a diarrhoeia, an abdominal pain, an anorexia, a hepatitis, a pancreatitis.
From respiratory system: an intersticial pneumonitis and other lesions of a pulmonary tissue.
From hemopoiesis system: an anaemia, a leukopenia, a thrombocytopenia, an agranulocytosis.
From genesial system: a transient oligospermatism, sterility.
Allergic reactions: a dermal eruption, a toxic epidermal necrolysis (Lyell's disease), a malignant exudative erythema (Stevens-Johnson's syndrome), a fever, an anaphylactic shock.
Contraindications
- A porphyria;
- An anaemia;
- The expressed disturbances of function of a liver;
- The expressed disturbances of function of kidneys;
- Deficiency of enzyme gljukozo-6-fosfatdegidrogenazy;
- Children's age till 5 years;
- The lactemia period;
- A hypersensibility to Sulfanilamidums and Acidum salicylicum derivatives.
Pregnancy and lactemia
Application to Azulfidine at pregnancy is possible only under strict indications in is minimum effective dose. If the disease current allows, it is recommended to cancel a preparation in III trimester of pregnancy.
In need of application of a preparation in a lactemia it is necessary to solve a question on the termination of thoracal feeding.
Azulfidine Special indicatings
With care it is necessary to prescribe a preparation to patients with disturbances of function of a liver and-or kidneys, to patients with a bronchial asthma, allergic reactions.
In preparation application the use of the raised quantity of a liquid is recommended.
In preparation application it is necessary to supervise level of hepatic enzymes, the general analysis of blood and urine.
Overdosage
Symptoms: a nausea, vomiting, abdominal pains, giddiness.
Treatment: a gastric lavage, an artificial diuresis; symptomatic therapy.
Azulfidine Medicinal interaction
At simultaneous application to Azulfidine reduces Acidum folicum and digoxin absorption.
At simultaneous application to Azulfidine strengthens action of anticoagulants, antiepileptic and peroral hypoglycemic preparations.
At simultaneous application to Azulfidine and antibiotics probably depression of efficiency to Azulfidine at an ulcerative colitis as antibiotics have oppressing an effect on intestinal flora.
Conditions and periods of storage
The preparation should be stored at temperature not above 25 C, in a place inaccessible to children. A period of validity - 5 years.
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