Celebrex
Celebrex
Celebrex (Celecoxib)Pharmacological action
A specific inhibitor of cyclooxygenase-2.
It is induced in reply to inflammatory process. It leads to synthesis , in particular, Prostaglandinum E2 that invokes an inflammation, an edema and a pain
Data of researches in vivo and ex vivo testify that Celebrex cyclooxygenase-1 possesses very low affinity to enzyme. Therefore at application in therapeutic Celebrex doses does not render influence on Prostaglandinums synthesised.
Indications
- An osteoarthrosis;
- A pseudorheumatism;
- A pain syndrome of a various aetiology (including postoperative, a dentagra, menstrual, osteal and muscular pains).
Dosing regimen
The adult at an osteoarthrosis the preparation is prescribed in a daily dose by of 200 mg in 1 or 2 receptions. In clinical researches doses to 400 mg/days were used
At a pseudorheumatism the preparation is prescribed in the daily dose by of 200-400 mg parted on 2 receptions. In clinical researches doses to 800 mg/days were used
At a pain syndrome the recommended single dose compounds 100-200 mg. If necessary probably subsequent application of a preparation in the same dose with an interval between receptions not less than 4-6 h before achievement of the maximum daily dose of 400 mg.
At an acute pain the recommended initial dose compounds 400 mg, then one more reception of a preparation in a dose of 200 mg is if necessary possible; the maximum dose in the first day of treatment - 600 mg/24h; the next days the preparation daily dose can vary from 200 mg to 400 mg.
Celebrex application at patients is more younger 18 years was not studied.
Side effect
From the alimentary system: often - an abdominal pain, a diarrhoeia, a dyspepsia; seldom - a nausea, vomiting, a heartburn, an anorexia; at long application in high doses - a mucosa ulceration GASTROINTESTINAL TRACT, a bleeding, a constipation, a meteorism, rising of activity of nuclear heating plant.
From party TSNS and peripheric excitatory system: seldom - a headache, giddiness, drowsiness or a sleeplessness, a sight illegibility, depression, excitation, confusion of consciousness, disturbing, hallucinations, audition depression, a sonitus.
From respiratory system: seldom - a pharyngalgia, tussis, a dyspnea, a bronchospasm.
From hemopoiesis system: seldom - an agranulocytosis, an anaemia, a leukopenia, a thrombocytopenia.
From cardiovascular system: seldom - an arterial hypertensia, an arrhythmia, inflow, palpitation, a congestive heart failure, a tachycardia.
Allergic responses: a violent dermal eruption, a Quincke's disease, a bronchospasm, an anaphylaxis, a vasculitis, Stevens-Johnson's syndrome.
The other: an alopecia, the raised diaphoresis, a nasal bleeding. There are separate reports on an acute pancreatitis.
Contraindications
- Indicatings in the anamnesis on allergic responses (an urticaria, a bronchospasm), bound to reception of Acidum acetylsalicylicum;
- The expressed disturbances of function of nephroses;
- The expressed disturbances of function of a liver;
- III trimester of pregnancy;
- A lactemia (thoracal feeding);
- Hypersensitivity to preparation components.
Pregnancy and lactemia
Preparation application at pregnancy (especially in III trimester) is possible only in that case when the prospective advantage for mother exceeds potential risk for a foetus.
In need of Celebrex application in a lactemia it is necessary to solve a question on the termination of thoracal feeding.
The special indicatings
It is necessary to apply Celebrex with guard at a stomach or duodenum peptic ulcer, an ulcerative colitis, a heart failure, a hydropic syndrome, an arterial hypertensia.
Celebrex is possible to apply with low doses of Acidum acetylsalicylicum. In connection with absence of action with thrombocytes Celebrex does not change Acidum acetylsalicylicum at preventive treatment of cardiovascular disturbances.
The control of laboratory indicators
During preparation application the control of a picture of peripheric blood and laboratory indicators of function of a liver and nephroses is necessary.
In need of definition 17-ketosteroidov the preparation is necessary for cancelling for 48 h before research carrying out.
Use in pediatrics
Clinical data about efficacyy and safety of Celebrex application at children and teenagers are elderly till 18 years are absent.
Influence on ability to driving of motor transport and to control of mechanisms
Potentially dangerous kinds of the activity demanding special attention and speed of psychomotor reactions, it is necessary to solve a question on possibility of employment only after an assessment of individual reaction of the patient on a preparation.
Overdosage
Clinical experience on an overdosage is not available. Healthy volunteers accepted unitary to 1200 mg and repeatedly to 1200 mg 2 times/sut without clinically significant adverse effects.
Treatment: spend symptomatic therapy. Hemodialysis carrying out noneffectively.
Conditions and periods of storage
The preparation should be stored in a dry place inaccessible to children at temperature from 15 to 30 C. The Period of validity - 3 years.
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