Motrin
Motrin (Ibuprofen)Structure
Active substance: Ibufrofenum.
Pharmacological action
Antiinflammatory, soothing, febrifugal. Slowly gets into a joint cavity, framing in it the big concentration, than in plasma. Is exposed to a biotransformation. It is deduced by kidneys. The antiinflammatory effect is bound to reduction of permeability of vessels, microcirculation improvement, depression of liberation from cells of mediators of an inflammation and suppression of power supply of inflammatory process. At unitary reception the effect proceeds to 8 h. Possesses the antipyretic effect which expression depends on an initial body temperature and a dose. Is reversible inhibits aggregation of thrombocytes.
Indications to application
Pseudorheumatism, reactive synovitis at a deforming osteoarthrosis, a psoriasis arthritis, acute articulate attack at a gout, an ankylosing spondylarthritis (Bekhterev's illness), a cervical spondylosis, a thoracal radicular syndrome, a bursitis, a neuralgic amyotrophia, an occipital and intercostal neuralgia, stretchings of the copular apparatus, a hematoma, a trauma, a pain in the field of an operational wound, a dentagra, surgical operations in oral cavities, a panniculitis, a tonsillitis, a pharyngitis, a laryngitis, a sinusitis, a rhinitis, a bronchitis, a pneumonia, inflammatory processes in a small basin, feverish conditions, a nephrotic syndrome (for reduction of expression of a proteinuria).
Contraindications
Hypersensitivity, stomach and duodenum peptic ulcer in an exacerbation phase, a nonspecific ulcerative colitis, a leukopenia, a thrombocytopenia, a hemorrhagic diathesis, serious disturbances of function of a liver and kidneys, a portal hypertensia, an arterial hypertensia, a heart failure, optic nerve diseases, a scotoma, an amblyopia, disturbance of colour sight, pregnancy, thoracal feeding.
Side effect
Dyspeptic disorders (a nausea, a heartburn, an anorexia, vomiting, discomfort in epigastric area, a meteorism, a diarrhoeia, an obstipation), erozivno-ulcer lesions GASTROINTESTINAL TRACT with signs of a gastroenteric bleeding, a headache, giddiness, a sonitus, a sleeplessness, excitation, sight disturbances (a veil before eyes, change of colour sight), a liquid delay, edemas, rising of arterial pressure, a thrombocytopenia, a granulocytopenia, a hemolitic anaemia, a Quincke's edema, dermal allergic reactions.
Overdosage
Symptoms: an abdominal pain, a nausea, vomiting, block, drowsiness, depression, a headache, a sonitus, a metabolic acidosis, a coma, acute renal insufficiency, a hypotension, a bradycardia, a tachycardia, fibrillation of auricles and respiratory standstill. Treatment: a gastric lavage (only within the first hour after reception), the activated coal (for absorption reduction), alkaline drink, an artificial diuresis and symptomatic therapy (correction of an acid-alkaline condition, arterial pressure, a gastroenteric bleeding).
Special indicatings
With care prescribe at children's age (till 12 years), to patients with serious disturbances of function of a liver and kidneys (the regular control of level of bilirubin, transaminases, a creatinine, concentration ability of kidneys is obligatory), an arterial hypertensia and a chronic heart failure (the daily control over a diuresis, body mass, arterial pressure). At occurrence of disturbances of sight it is necessary to reduce a dose or to cancel a preparation. The use of alcoholic drinks in treatment is not recommended.sms.
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