Toradol
Toradol
Toradol (Ketorolac)Pharmacological action
The action mechanism is caused by oppression of enzyme of cyclooxygenase (basically in peripheric tissues), a consequence of it is inhibition of synthesis of Prostaglandinums.
Toradol oppresses aggregation of thrombocytes and enlarges a bleeding time. The functional condition of thrombocytes is restored through 24-48 h after preparation cancellation.
Indications
- Cupping of a painful syndrome of strong and average intensity (including at traumas, in the postoperative period, at a radicular syndrome).
Dosage regimen
Prescribe a preparation inside in a dose of 1 times/days of 10 mg If necessary prescribe on 10 mg everyone 4-6 h. The maximum daily dose - 40 mg (4 tablets.). Duration of reception - no more than 7 days.
Toradol Side effect
From the alimentary system: most often (about 5-10 %) pains in the field of a stomach and an intestine, a diarrhoeia become perceptible a nausea; seldom - vomiting, a constipation, a meteorism, an eructation, appetite disturbance; very seldom - disturbances of function of a liver and a pancreas, gastroenteric bleedings.
From party TSNS and peripheric nervous system: a headache, drowsiness, giddiness; seldom - nervousness, dream disturbances, euphoria, an asthenia, intensifying of a diaphoresis, sight disturbance, impellent disorders, paresthesias.
From respiratory system: seldom - a dyspnea, tussis, a fluid lungs.
From cardiovascular system: an arterial hypertensia, palpitation, a syncope.
From system of coagulation of blood: seldom - nasal bleedings, an anaemia, an eosinophilia, a thrombocytopenia, bleedings from postoperative wounds.
Allergic reactions: a dermal itch, a hemorrhagic eruption; very seldom - an exfoliative dermatitis, an urticaria, a Lyell's disease, Stevens-Johnson's syndrome, an anaphylactic shock, a bronchospasm, a Quincke's edema.
The other: a fever, dryness in a mouth.
Toradol Contraindications
- A stomach and duodenum peptic ulcer in an exacerbation phase;
- Punching, a gastroenteric bleeding in the anamnesis;
- The moderate and serious renal insufficiency at a hypovolemia and a dehydration;
- A bronchial asthma;
- Nasal cavity polyps;
- A Quincke's disease in the anamnesis;
- Intracraneal hemorrhage;
- Conditions with high risk of a bleeding;
- Simultaneous reception of Acidum acetylsalicylicum;
- Pregnancy;
- A lactemia (thoracal feeding);
- Labours;
- Preventive anaesthesia before operation and during operation;
- Children's and teenage age till 16 years;
- A hypersensibility to preparation components, Acidum acetylsalicylicum.
Pregnancy and lactemia
Toradol is contraindicative to application at pregnancy, sorts and in a lactemia (thoracal feeding).
Special indicatings
It is necessary to consider, that for the prevention of possible side-effects it is necessary to use is minimum effective doses of a preparation, to consider a condition of the patient (age, function of kidneys, GASTROINTESTINAL TRACT, a condition of vodno-electrolytic balance, hemostasis system).
Influence on ability to driving of motor transport and to management of mechanisms
To the patients accepting Toradol preparation, it is necessary to abstain from employment by potentially dangerous kinds of the activity, demanding special attention and speed of psychomotor reactions.
Toradol Overdosage
Symptoms: pains in the field of a stomach, a nausea, vomiting, erozivno-ulcer lesions GASTROINTESTINAL TRACT, disturbances of function of kidneys, intensifying and breath increase.
Treatment: the gastric lavage with the subsequent appointment of the activated coal or other adsorbents is recommended. Symptomatic therapy is shown. At development of renal insufficiency dialysis appointment is possible. However at a dialysis Ketorolac slightly leaves from plasma.
Conditions and periods of storage
The preparation should be stored in the dry place protected from light. A period of validity - 2 years.
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