Tramadol
Concerns to analgesic with centrally acting. Renders the expressed anesthetizing effect.Tramadol renders anti-cough action also, does no influence on gastroenteric path. Duration of action for about 4-8 hours.
After using practically all tramadol (90%) quickly soaked up from a stomach.
The maximal concentration in blood's plasma is defined approximately in 2 hours. The size of biological availability makes about 70 %, does not depend on food taken and increases at repeated using of a preparation.
Linkage with plasma's fibers makes about 20 %. There is 0,1 % of tramadol secreted with a mother's milk.
Tramadol is deduced basically by kidneys (up to 90 %) and through intestines (about 10 %). The deduced period, irrespective of a way of introduction, makes about 6 hours.
An advanced age patients, with a liver cirrhosis of and at renal failure the size of the period of deducing increases.
Tramadol is used when you have:
Painful syndrome of average and strong intensity various ethiology (the postoperative period, traumas, hurt oncological patients).
Tramadol is used with the purpose of anesthesia at carrying out of painful diagnostic or medical manipulations.
Contraindications:
The conditions, accompanied oppression of breath or the expressed oppression of the central nervous system (an alcoholic poisoning, somnolent preparations,psychotropic means). Pregnancy and the period of a lactation. Age till 14 years.
Pregnancy and the breast feeding period:
At pregnancy it is necessary to avoid long application of tramadol.
It's necessary to remember that some tramadol (0,1%) secreted with the mother's milk.
Tramadol usage:
A dose is selected by the doctor individually and depends on pain's intensity and pain'scharacter
Usual dose - 1 tablet or a capsule (50 mg) inside with a small amount of a liquid irrespective of time of food intake.
If there is no effect during 30 - 60 minutes it is possible to intake 1 more tablet or a capsule.
At strong pains the unitary doze can make at once 100 mg (2 tablets or capsules).
The effect is kept within 4-8 hours.
It is not recommended to exceed a day time dose of Tramadol 400 mg (8 tablets or capsules).
It is not recommended to give tramadol to children with weight of a body less than 25 kg and in the age less than 14 years also.
Duration and the scheme of usage are defined by the doctor.
Capsule it is necessary to swallow not chewing, washing down with necessary quantity of a liquid, irrespective of reception of food. It is possible to swallow of tablets not chewing, washing down with necessary quantity of a liquid, irrespective of reception of food, or preliminary to dissolve in 1/2 glasses of water. Collateral actions: Most typical dizziness, a nausea, locks, a headache, drowsiness (these by-effects meet at 30 - 15 % of the patients accepting Tramadol), vomiting, a skin itch, dryness in a mouth, a diarrhea (meet at 15 - 5 % of patients). With frequency less than 5 % are possible loss of weight, a hypotension and a tachycardia, hallucinations, a tremor, pains in the field of a stomach, infringements of sight. Frequency of development of by-effects raises with increase in duration of reception of a preparation. At long application in greater dozes the opportunity of development of medicinal dependence is not excluded. About all by-effects, including not specified above, it is necessary to inform the attending physician. Overdose (intoxication) by a preparation: the Most dangerous consequences of overdose by tramadol are narrowing pupils, vomiting, oppression of breath and a spasm.
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