Trental
Trental
Trental (Pentoxifylline)Pharmacological action
The preparation enriching microcirculation.
Inhibits aggregation of thrombocytes and erythrocytes, raises their flexibility, reduces the raised concentration of a fibrinogen in plasma and enhances a fibrinolysis that reduces viscosity of blood and enriches its rheologic properties. At preparation application enriching of microcirculation and supply of tissues by oxygen, to the greatest degree - in extremities, in moderate degree - in nephroses becomes perceptible. The preparation slightly dilates coronary pots. Thanks to features of the medicinal form continuous liberation of awake material during 12 h is reached, that provides high efficacyy of a preparation.
Trental Indications
- An atherosclerotic encephalopathy;
- An ischemic cerebral stroke;
- The disturbances of a peripheric circulation caused by an atherosclerosis, a diabetes, an inflammation;
- The trophic disturbances of tissues bound to a lesion of arteries, veins or with microcirculation disturbance (trophic ulcers, a gangrene, a freezing injury);
- An obliterating endarteritis;
- Disturbances of a circulation of an eye (an acute, subacute and chronic circulatory unefficiency in a retina and in a choroid);
- Disturbances of function of an intrinsic ear of the vascular character, accompanied by relative deafness.
Trental Dosing regimen
Establish individual, depending on severity level of disturbance of blood supply, from mass of a body and from shipping of therapy. A preparation recommend to introduce i.v. in the form of infusion since it is the most effective and easily transferable form of parenteral introduction of a preparation.
Recommend the following scheme of therapy.
The preparation is introduced in the form of infusion on 200-300 mg by 2 times/sut (in the morning and in the afternoon). At a grave condition of the patient probably carrying out of long infusion of Trental during 24 h. Thus the dose is defined from calculation of mass of a body by of 0.6 mg/kg at an o'clock. For the patient with mass of a body the dose calculated thus compounds 70 kg 1 g, for the patient with mass of a body 80 kg - 1.15 the Maximum dose should not exceed 1.2 Volume of infusional solution establish individual, taking into account concomitant diseases. The average volume compounds 1-1 l for 24 h.
In some cases the preparation is applied in a kind i.v. injections in a dose by of 100 mg (5 ml of solution). An injection spend slowly; 5 ml of solution introduce within 5 minutes During carrying out of an injection the patient should be in a prone position.
In addition to parenteral introduction Trental is prescribed inside in a dose by of 800 mg after diurnal infusion; at a long interspace between infusions prescribe in addition 400 mg between introductions. In case of carrying out of infusion of 1 times/sut in the morning in prescribe on 800 mg in the afternoon and 400 mg - in the evening.
Rules of preparation and introduction of infusional solution
For preparation of infusional solution contents of 2 ampulas on 5 ml (100 mg) or 1 ampulas on 15 ml (300 mg) solution for injections plant 250 ml or 500 ml of solution Trental of Sodium lactatum, a normal saline solution, 5 % of solution of a glucose. Duration of infusion compounds 120-180 minutes
Trental Side effect
From the alimentary system: a nausea, vomiting, sense of gravity in epigastriums, a diarrhoeia.
From party TSNS: seldom - a headache, giddiness.
Allergic responses: a dermal eruption, an itch, an urticaria, a Quincke's edema.
The other: in single instances - bleedings from pots of a skin and mucosas.
Trental Contraindications
- An acute myocardial infarction;
- A massive bleeding;
- A hematencephalon;
- A massive retinal apoplexy of an eye;
- Pregnancy;
- A lactemia (thoracal feeding).
Trental Pregnancy and lactemia
Trental is contraindicative to application at pregnancy.
In need of application of a preparation in a lactemia it is necessary to stop thoracal feeding.
The special Trental indicatings
It is necessary to be careful at appointment of Trental to patients with a stomach and duodenum peptic ulcer in the anamnesis; to the patients who have recently tolerated an operative measure (the risk of occurrence of a bleeding in this connection the regular control of level of haemoglobin and a hematocrit is necessary is raised).
To patients with an arterial hypotension and a labile circulation parenteral introduction of Trental prescribe gradually, as probably depression of a BP (up to a collapse), and on occasion - stenocardia attacks.
With a heart failure carrying out of the conforming treatment for the purpose of circulation indemnification is necessary for patients. Thus it is necessary to avoid introduction of great volume of fluids.
To patients with disturbances of function of nephroses the dosing regimen should be selected individual.
Trental Overdosage
Symptoms: in the beginning the nausea, giddiness, a tachycardia, BP depression are possible; further - rise in temperature, excitation, a loss of consciousness, an areflexia, kloniko-tonic cramps, phylum vomiting "coffee ground" (as a sign of a gastrointestinal bleeding).
Treatment: the specific antidote is unknown.
Treatment of an acute overdosage and the prevention of complications can demand carrying out of special urgent actions.
Pharmaceutical interaction.
Trental solution is compatible to a normal saline solution, 5 % glucose and levulose solution. In other cases it is necessary to supervise compatibility of applied infusional solutions.
Conditions and periods of storage
Tablets should be stored in a dry, cool place. Solution for injections should be stored in a cool, dark place. A preparation period of validity - 5 years.
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