Betnovate
Betnovate
Betnovate (Betamethasone)Pharmacological action
For outside application. The expressed antiinflammatory, immunodepressive and antiproliferative an effect has. It is characterised by high degree of glucocorticoid activity at insignificant effect.
Reduces formation, liberation and activity of chemical mediators of an inflammation ( Histaminum, Prostaglandinums), reduces a hyperpermeability of pots, inhibits migration of cells to an inflammation place that interferes with edema occurrence. Inhibits III and IV phylum of reactions of hypersensitivity, quenching effect of complexes antigen-antibody which concentrate on sides of veins, and also inhibiting action of lymphokines, target cells and macrophages. Besides, prevents access T lymphocytes and macrophages to target cells.
Presence in a fluorine molecula enhances antiinflammatory activity of betamethasone.
Indications
- Allergic diseases of a skin (including an acute, subacute and chronic contact dermatitis, a professional dermatitis, a seborrheal dermatitis, a neurodermite, dermatitis, a dermal itch);
- Acute and chronic forms of not allergic dermatitises (including photodermatites, a radial dermatitis, reactions to punctures of hexapods);
- A psoriasis;
- A pemphigoid;
- An exfoliative dermatitis;
- Flat red deprive;
- An erythrosis;
Cream apply at acute soaked lesions of a skin, and ointment - at chronic dermatoses, dry, husking lesions when occlusal action of ointment as is necessary mediums.
Dosing regimen
Ointment or cream put to adults on the amazed field of a skin 2 times/sut a flake, slightly rubing. On integuments with more dense false skin from which the preparation can be easily erased at a normal mode of life (palms and soles), should put a preparation brake. Duration of treatment should compound no more than 3 weeks.
For preventive maintenance of relapses at treatment of chronic diseases therapy should be continued during some time after petering of all symptoms.
To children the preparation should be prescribed with guard and to as much as possible short term because at children because of larger than at adults of an interrelation of the area of a surface of integuments and mass of a body and a false skin underdevelopment, the adsorption of proportionally larger quantity of betamethasone is possible at aboriginal application. Application under diapers also enhances a system adsorption, since. Diapers react as an occlusive bandage.
If time of drawing of a preparation is passed, it is necessary to put it on the amazed surface as soon as possible; if time of use of the following dose comes nearer, the passed dose to apply does not follow; to enlarge quantity of a preparation at following drawing does not follow.
Side effect
Aboriginal reactions: atrophic changes of a skin; at long therapy - an itch, a hirsutism, a hyperpegmentation and a depigmentation of a skin, a hair, disturbance of function of sebaceous glands.
System reactions: depressing of function of gipotalamo-gipofizarno-adrenal system, tolerance depression to carbohydrates; at children - a growth inhibition, intracranial pressure rising, depression of mass of a body, depression of level of a hydrocortisone in plasma and urine.
Contraindications
- Virus infection contaminations of a skin;
- A tuberculosis cutis;
- A perioral dermatitis;
- Dermal reactions to a bacterination place;
- Hypersensitivity to a preparation.
Pregnancy and lactemia
Adequate and well controllable researches of safety of outside application at pregnancy it was not spent. Therefore Betnovate application is possible only when the prospective advantage for mother exceeds potential risk for a foetus. In such cases preparation application should be short and confine a small field of integuments.
In a lactemia Betnovate application is possible only under strict indications, but thus it is impossible to put a preparation on a mammary gland skin before feeding.
In experimental researches it is established, that at outside application strong at laboratory animals the teratogenic effect becomes perceptible.
The special indicatings
In case at first Betnovate application hypersensitivity reactions educe (an itch, a burning sensation and a redness) it is necessary to stop preparation use immediately.
Long Betnovate application on a face skin as development розацеа is possible, a perioral dermatitis is not recommended.
Betnovate is not necessary to use in the field of eyes as development of a cataract in this case is possible, glaucomas, fungoid infection contaminations of eyes.
It is not recommended to use Betnovate on a pilar part of a head.
Betnovate do not use for treatment of varicose ulcers of an anticnemion.
System by-effects from endocrine system can educe in case of preparation application on the big surfaces of the amazed skin, in case of preparation application for a long time and at use of occlusive bandages, and also at patients with disturbances of function of a liver, since in these cases probably intensifying of an adsorption of betamethasone. These by-effects educe exclusively seldom, have reversible character and disappear at once after the therapy termination. At these categories of patients in preparation application the regular control of function of gipotalamo-gipofizizarno-adrenal system is necessary. At appearance of symptoms of depressing of its function it is necessary to stop use of a preparation or to enlarge intervals between applications, or to change a preparation with more weak. In such cases the withdrawal very seldom can educe, that demands system replaceable therapy by glucocorticoids.
Some fields of a body, such as axillary recesses, perianal range where there is some kind of natural an occlusion, therefore preparation application in these ranges should be short.
In cases of development of a fungoid or bacteriemic superinfection additional application of an antimicotic or antimicrobic agent is necessary.
Use in pediatrics
At children probably development of system side-effects from endocrine system because of possible intensifying of an adsorption of betamethasone.
Overdosage
Symptoms: at betamethasone use on the big surfaces of the amazed skin, for a long time (more than 3 weeks), with occlusive bandage use, and also at long use at children, are possible intensifying of system by-effects of betamethasone.
Treatment: the preparation should be cancelled. If necessary spend symptomatic therapy.
Medicinal interaction
Clinical interaction of Betnovate preparation with other medical products is not described.
Conditions and periods of storage
The preparation should be stored at temperature not above 25 C The Period of validity - 4 years.
Buy Betnovate online
Here you can order Betnovate online. Cheap Betnovate just click the link below.
$22.74
