Zyban
Zyban
Zyban (Bupropion)Bupropion- the pharmaceutical antidepressant working as an inhibitor of Dopaminum which operates immediately on a brain and other nerve ganglions. It is used for treatment of a carelessness, bipolar depression, a syndrome of chronic weariness, nicotinic and cocainic dependence, and as pains in a backbone. Bupropion is considered an antidepressant of the second generation, or an atypical antidepressant because of difference of its action from action of similar preparations of the first generation.
In the USA Bupropion is on sale as an antidepressant under the brand "Wellbutrin" and under the brand "Zyban". The hydrochloride of Bupropion represents a crystalline powder well soluble in water, bitter on taste.
The use
The maximum of 450 mg a day registers on 75-300.
Effects
Zyban sometimes is used alternatively to an amphetamine in cases of a depressive syndrome and a syndrome of deficiency of attention/hyperactivity. The effect can be felt in 60-90 minutes after acceptance. The effect from 12 lasts till 24 o'clock, however active metabolites have a half-life period 20-34 hours. By-effects: anxiety, disturbing reactions, the discomfort, dryness in a mouth, giddiness, a nausea, a headache, a tremor.
By-effects
Dermal reactions, psychological disturbances and nervous breakdowns, urticaria, nausea, giddiness concern them, a headache, a tremor, and sometimes even fury. Except the listed by-effects there is one more problem - probability of an epileptic attack. Successors of the people, suffering are subject to it by an epilepsy basically. At reception of 300 mg/day the probability of occurrence of this problem makes 0,1 %. At augmentation of a daily dose at 100 mg the probability increases in 4 times and consists 0,4 %. Therefore it is not recommended to exceed a dose in 200 mg.
As well as the majority of stably accepted antidepressants, Zyban causes some dependence, both physiological, and psychological. Therefore at refusal of a preparation doctors do not recommend to stop sharply reception of Zyban , gradual refusal of a preparation is recommended.
Contraindications
Not to use in a combination with MAOI, after last reception MAOI before reception of Zyban should pass not less than 14 days. Some people noted unpleasant effects at reception of other psychoactive substances in the stable use of Zyban.
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