Xenical
Xenical
Xenical (Orlistat)Indications
- Adiposity and superfluous mass of a body (in a combination to moderately hypohigh-calorie diet).
Dosage regimen
Prescribe on 120 mg 3 times/sut together with the basic food intakes. A preparation accept during meal or not later than through 1 h after meal. In case food intake pass or if the nutrition does not contain some Adeps, Xenical reception can be passed.
The augmentation of a dose above the recommended does not lead to augmentation of therapeutic effect.
Side effect
From the alimentary system: allocation from a rectum, allocation of gases, imperative desires on a defecation, a steatorrhea, increase of a defecation and a feces incontience (as a rule, these phenomena have transient character and arise in the first 3 motths treatments); seldom - pains or discomfort in a stomach, a meteorism, a liquid chair, pains or discomfort in a rectum.
Allergic reactions: a dermal eruption, an itch, a Quincke's disease, anaphylactic reactions.
Contraindications
- A cholestasia;
- A hypersensibility to a preparation.
Pregnancy and lactemia
Xenical it is not necessary to prescribe at pregnancy, in connection with absence of the authentic clinical data confirming safety of its application.
It is not established, whether gets Orlistatinto thoracal milk in this connection Xenical application in a lactemia (thoracal feeding) do not recommend.
Special indicatings
Against Xenical therapy the patient should receive the balanced, moderately hypohigh-calorie diet containing no more of 30 % of calories in the form of Adepses. At higher maintenance of Adepses in a food allowance the probability of occurrence of collateral reactions from the party GASTROINTESTINAL TRACT raises.
Depression of mass of a body of patients can improve a metabolism at patients with a diabetes and demand a dose decline of peroral antidiabetic preparations.
Safety and efficiency of Xenical application at patients with disturbances of function of a liver and-or kidneys is not established.
In clinical researches at the majority of the patients receiving Xenical within 2 full years, concentration of vitamins A, D, E, To and beta carotin remained within norm. In some cases for adequate entering of all nutrients in an organism it is possible to prescribe Polyvitaminums which follow to accept not less, than through 2 h after Xenical reception or before a dream.
Use in pediatrics
Safety of application of a preparation at children is not established.
Overdosage
Overdosage cases it is not described. In clinical researches reception of a single dose of 800 mg or a multiple dose on 400 mg 3 times/sut within 15 days were not accompanied by appreciable undesirable reactions. There is an experience of application of a preparation on 240 mg 3 times/sut within 6 months
Treatment: in case of the expressed overdosage recommend medical observation during 24 h.
Medicinal interaction
Medicinal interaction is not established at the same Xenical application with digoxin, warfarin, Metforminum, peroral contraceptives, nifedipine and ethanol.
At simultaneous Xenical application can reduce an absorption of liposoluble vitamins.
Conditions and periods of storage
The preparation should be stored in a dry place at temperature not above 25 C. The Period of validity - 3 years.
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